MAFF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	22 studies	36% ± 18%	Explore
natural killer cell	18 studies	24% ± 12%	Explore
endothelial cell	18 studies	37% ± 13%	Explore
smooth muscle cell	17 studies	41% ± 18%	Explore
pericyte	15 studies	46% ± 20%	Explore
endothelial cell of lymphatic vessel	12 studies	38% ± 18%	Explore
epithelial cell	12 studies	39% ± 21%	Explore
basal cell	12 studies	36% ± 15%	Explore
conventional dendritic cell	11 studies	26% ± 12%	Explore
endothelial cell of vascular tree	10 studies	38% ± 13%	Explore
macrophage	9 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	32% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	24% ± 10%	Explore
dendritic cell	8 studies	30% ± 6%	Explore
secretory cell	8 studies	43% ± 15%	Explore
classical monocyte	7 studies	21% ± 5%	Explore
connective tissue cell	7 studies	33% ± 16%	Explore
ciliated cell	6 studies	36% ± 23%	Explore
capillary endothelial cell	6 studies	30% ± 9%	Explore
myofibroblast cell	6 studies	36% ± 25%	Explore
innate lymphoid cell	6 studies	28% ± 9%	Explore
monocyte	5 studies	21% ± 5%	Explore
myeloid cell	5 studies	36% ± 16%	Explore
leukocyte	5 studies	24% ± 6%	Explore
squamous epithelial cell	4 studies	47% ± 21%	Explore
mature NK T cell	4 studies	19% ± 3%	Explore
gamma-delta T cell	4 studies	28% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 15%	Explore
vein endothelial cell	4 studies	31% ± 13%	Explore
type I pneumocyte	3 studies	24% ± 3%	Explore
club cell	3 studies	35% ± 15%	Explore
abnormal cell	3 studies	30% ± 13%	Explore
kidney loop of Henle epithelial cell	3 studies	27% ± 9%	Explore
mucosal invariant T cell	3 studies	27% ± 3%	Explore
retinal pigment epithelial cell	3 studies	25% ± 9%	Explore
endothelial cell of artery	3 studies	40% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	43% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	52% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	32% ± 10%	Explore
uterus	5 studies	41% ± 12%	Explore
prostate	4 studies	34% ± 12%	Explore
breast	4 studies	37% ± 17%	Explore
placenta	3 studies	26% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	99%	4262.59	1788 / 1809	99%	25.35	468 / 472
lung	99%	6674.84	573 / 578	98%	17.13	1135 / 1155
prostate	98%	4656.51	239 / 245	100%	30.60	500 / 502
bladder	95%	4765.90	20 / 21	99%	25.87	499 / 504
esophagus	95%	3713.35	1367 / 1445	98%	17.85	180 / 183
breast	100%	8340.44	459 / 459	91%	11.87	1021 / 1118
uterus	92%	4488.79	157 / 170	97%	21.48	446 / 459
ovary	97%	5781.66	175 / 180	86%	10.48	368 / 430
intestine	81%	2601.78	786 / 966	99%	16.86	524 / 527
stomach	80%	3890.16	286 / 359	99%	14.25	282 / 286
kidney	82%	3094.53	73 / 89	93%	17.33	835 / 901
thymus	92%	3040.44	600 / 653	82%	18.05	497 / 605
liver	42%	1616.88	96 / 226	83%	12.72	337 / 406
adrenal gland	55%	1860.81	142 / 258	64%	9.23	147 / 230
pancreas	20%	294.36	64 / 328	99%	34.36	176 / 178
brain	31%	730.74	814 / 2642	71%	8.96	501 / 705
tonsil	0%	0	0 / 0	100%	17.16	45 / 45
ureter	0%	0	0 / 0	100%	52.82	1 / 1
adipose	100%	9519.67	1203 / 1204	0%	0	0 / 0
blood vessel	100%	7603.45	1331 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	14.00	79 / 80
muscle	87%	4743.92	700 / 803	0%	0	0 / 0
heart	64%	2833.49	555 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	52%	3.62	15 / 29
peripheral blood	47%	1256.43	440 / 929	0%	0	0 / 0
spleen	38%	660.22	91 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0001701	Biological process	in utero embryonic development
GO_0045604	Biological process	regulation of epidermal cell differentiation
GO_0007567	Biological process	parturition
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding

IV. Literature review

[source]

Gene name	MAFF
Protein name	Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) MAF bZIP transcription factor F
Synonyms
Description	FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves . However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene . May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition . .
Accessions	ENST00000338483.7 [Q9ULX9-1] Q9ULX9 ENST00000538320.5 [Q9ULX9-1] ENST00000407965.1 [Q9ULX9-1] ENST00000538999.1 [Q9ULX9-2] ENST00000441709.1 ENST00000417948.5 B0QY70 B0QY71 ENST00000426621.6 [Q9ULX9-1]

MAFF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review