IGF2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IGF2 at tissue level.

III. Associated gene sets

GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0051781Biological processpositive regulation of cell division
GO_0001701Biological processin utero embryonic development
GO_0001892Biological processembryonic placenta development
GO_0051147Biological processregulation of muscle cell differentiation
GO_0001649Biological processosteoblast differentiation
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0009887Biological processanimal organ morphogenesis
GO_0060669Biological processembryonic placenta morphogenesis
GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_0071514Biological processgenomic imprinting
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_0031017Biological processexocrine pancreas development
GO_0051146Biological processstriated muscle cell differentiation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045725Biological processpositive regulation of glycogen biosynthetic process
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_0008286Biological processinsulin receptor signaling pathway
GO_0048633Biological processpositive regulation of skeletal muscle tissue growth
GO_0006355Biological processregulation of DNA-templated transcription
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0046622Biological processpositive regulation of organ growth
GO_0006006Biological processglucose metabolic process
GO_0040018Biological processpositive regulation of multicellular organism growth
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0005158Molecular functioninsulin receptor binding
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0048018Molecular functionreceptor ligand activity
GO_0005179Molecular functionhormone activity
GO_0008083Molecular functiongrowth factor activity
GO_0005178Molecular functionintegrin binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIGF2
Protein nameInsulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
Insulin-like growth factor II
SynonymsPP1446
DescriptionFUNCTION: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling . Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). .; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. .

FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. .

FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. .

AccessionsENST00000695541.1 [P01344-1]
P01344
E3UN46
ENST00000381395.5 [P01344-1]
ENST00000481781.3 [P01344-1]
ENST00000381406.8 [P01344-2]
ENST00000418738.2 [P01344-1]
B2MUX6
ENST00000434045.6 [P01344-3]
ENST00000381392.5 [P01344-2]
ENST00000381389.5 [P01344-1]
ENST00000416167.7 [P01344-1]