Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 13 studies | 21% ± 7% | |
| lung | 9 studies | 26% ± 12% | |
| brain | 6 studies | 30% ± 6% | |
| intestine | 5 studies | 29% ± 14% | |
| kidney | 4 studies | 18% ± 3% | |
| eye | 4 studies | 24% ± 8% | |
| uterus | 4 studies | 27% ± 11% | |
| lymph node | 4 studies | 21% ± 6% | |
| bone marrow | 3 studies | 20% ± 4% | |
| adrenal gland | 3 studies | 19% ± 2% | |
| liver | 3 studies | 34% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 6107.08 | 359 / 359 | 100% | 68.20 | 286 / 286 |
| uterus | 100% | 9288.79 | 170 / 170 | 100% | 103.96 | 459 / 459 |
| breast | 100% | 5294.77 | 459 / 459 | 100% | 101.20 | 1117 / 1118 |
| prostate | 100% | 6818.53 | 245 / 245 | 100% | 55.30 | 501 / 502 |
| ovary | 100% | 13007.66 | 180 / 180 | 100% | 62.85 | 429 / 430 |
| lung | 100% | 4777.58 | 576 / 578 | 100% | 56.58 | 1154 / 1155 |
| esophagus | 100% | 7280.45 | 1445 / 1445 | 99% | 55.75 | 182 / 183 |
| intestine | 100% | 7291.11 | 966 / 966 | 99% | 71.33 | 524 / 527 |
| bladder | 100% | 6859.81 | 21 / 21 | 99% | 67.64 | 501 / 504 |
| thymus | 100% | 5298.95 | 652 / 653 | 99% | 59.94 | 601 / 605 |
| brain | 99% | 4065.04 | 2620 / 2642 | 100% | 73.18 | 705 / 705 |
| skin | 100% | 6456.39 | 1809 / 1809 | 99% | 63.33 | 467 / 472 |
| adrenal gland | 100% | 25598.21 | 258 / 258 | 99% | 95.02 | 227 / 230 |
| pancreas | 100% | 3145.80 | 327 / 328 | 99% | 50.09 | 176 / 178 |
| kidney | 100% | 3986.66 | 89 / 89 | 98% | 37.63 | 885 / 901 |
| liver | 94% | 2079.53 | 212 / 226 | 96% | 32.93 | 391 / 406 |
| adipose | 100% | 4976.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 7401.40 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 90.45 | 29 / 29 |
| muscle | 100% | 8318.50 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5223.63 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 75.83 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 30.58 | 1 / 1 |
| heart | 95% | 4839.70 | 820 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 31.32 | 76 / 80 |
| peripheral blood | 73% | 3368.41 | 674 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1902455 | Biological process | negative regulation of stem cell population maintenance |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_2000736 | Biological process | regulation of stem cell differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006260 | Biological process | DNA replication |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0070370 | Biological process | cellular heat acclimation |
| GO_0042659 | Biological process | regulation of cell fate specification |
| GO_1902459 | Biological process | positive regulation of stem cell population maintenance |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0007420 | Biological process | brain development |
| GO_0048545 | Biological process | response to steroid hormone |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0070822 | Cellular component | Sin3-type complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000118 | Cellular component | histone deacetylase complex |
| GO_0035098 | Cellular component | ESC/E(Z) complex |
| GO_0005829 | Cellular component | cytosol |
| GO_1904949 | Cellular component | ATPase complex |
| GO_0016581 | Cellular component | NuRD complex |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0016589 | Cellular component | NURF complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0042393 | Molecular function | histone binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RBBP7 |
| Protein name | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) Histone-binding protein RBBP7 (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) RB binding protein 7, chromatin remodeling factor |
| Synonyms | RBAP46 hCG_20110 |
| Description | FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. . |
| Accessions | ENST00000468092.1 ENST00000425696.5 Q5JP01 Q16576 Q6FHQ0 C9JAJ9 ENST00000493145.1 ENST00000416035.1 Q5JNZ6 E9PC52 ENST00000380087.7 [Q16576-1] ENST00000444437.5 ENST00000380084.8 [Q16576-2] ENST00000404022.5 C9J7L0 Q5JP02 |
