ATF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0006094Biological processgluconeogenesis
GO_0034198Biological processcellular response to amino acid starvation
GO_1903984Biological processpositive regulation of TRAIL-activated apoptotic signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0035914Biological processskeletal muscle cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_1990622Cellular componentCHOP-ATF3 complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATF3
Protein nameCyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Activating transcription factor 3
Activating transcription factor 3 delta Zip3 (cDNA FLJ57271, highly similar to Cyclic AMP-dependent transcription factorATF-3)
Synonyms
DescriptionFUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. .; FUNCTION: [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. .; FUNCTION: [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1. .

AccessionsP18847
ENST00000366987.6 [P18847-1]
ENST00000336937.8 [P18847-4]
ENST00000366981.8
ENST00000613104.1 [P18847-5]
ENST00000366983.5 [P18847-3]
ENST00000341491.9 [P18847-1]
Q5VTZ4
Q7Z567
A0A0A0MRJ2
ENST00000366985.5
ENST00000464547.5 [P18847-3]