KAT2B | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	18 studies	43% ± 18%	Explore
oligodendrocyte	15 studies	45% ± 16%	Explore
oligodendrocyte precursor cell	15 studies	69% ± 18%	Explore
endothelial cell	12 studies	28% ± 13%	Explore
microglial cell	9 studies	25% ± 7%	Explore
GABAergic neuron	7 studies	35% ± 14%	Explore
macrophage	6 studies	24% ± 9%	Explore
T cell	6 studies	26% ± 7%	Explore
interneuron	5 studies	33% ± 15%	Explore
endothelial cell of lymphatic vessel	5 studies	39% ± 11%	Explore
cardiac muscle cell	4 studies	20% ± 4%	Explore
glutamatergic neuron	4 studies	37% ± 13%	Explore
dendritic cell	4 studies	21% ± 7%	Explore
B cell	4 studies	23% ± 7%	Explore
natural killer cell	4 studies	31% ± 5%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	61% ± 6%	Explore
retinal pigment epithelial cell	3 studies	25% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	25% ± 9%	Explore
CD4-positive, alpha-beta T cell	3 studies	39% ± 5%	Explore
CD8-positive, alpha-beta T cell	3 studies	29% ± 4%	Explore
epithelial cell	3 studies	42% ± 23%	Explore
retinal rod cell	3 studies	27% ± 3%	Explore
fibroblast	3 studies	23% ± 5%	Explore
Schwann cell	3 studies	38% ± 20%	Explore
lymphocyte	3 studies	55% ± 17%	Explore
adipocyte	3 studies	17% ± 1%	Explore
mast cell	3 studies	21% ± 6%	Explore
regulatory T cell	3 studies	34% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	32% ± 16%	Explore
eye	4 studies	26% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5083.26	2642 / 2642	100%	88.45	704 / 705
prostate	100%	2616.82	245 / 245	99%	24.71	496 / 502
thymus	100%	3380.18	652 / 653	98%	27.68	595 / 605
pancreas	98%	1472.02	322 / 328	96%	14.64	170 / 178
skin	99%	2056.72	1795 / 1809	94%	48.82	443 / 472
kidney	99%	1696.40	88 / 89	93%	19.43	838 / 901
esophagus	100%	3583.46	1445 / 1445	91%	15.08	166 / 183
lung	100%	2771.49	576 / 578	89%	12.50	1031 / 1155
liver	99%	1936.01	223 / 226	89%	17.18	360 / 406
breast	100%	2325.98	458 / 459	86%	11.71	961 / 1118
bladder	100%	2479.48	21 / 21	85%	13.15	428 / 504
ovary	100%	3153.51	180 / 180	83%	10.30	357 / 430
uterus	100%	2459.56	170 / 170	80%	12.27	369 / 459
adrenal gland	96%	1427.11	248 / 258	83%	11.83	191 / 230
stomach	100%	2372.25	359 / 359	78%	10.41	223 / 286
intestine	100%	2970.13	966 / 966	69%	7.91	362 / 527
blood vessel	100%	3371.36	1335 / 1335	0%	0	0 / 0
muscle	100%	4905.39	803 / 803	0%	0	0 / 0
spleen	100%	2901.57	241 / 241	0%	0	0 / 0
adipose	100%	2820.59	1203 / 1204	0%	0	0 / 0
peripheral blood	98%	2237.69	906 / 929	0%	0	0 / 0
heart	97%	3080.20	832 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	15.59	42 / 45
lymph node	0%	0	0 / 0	93%	21.55	27 / 29
eye	0%	0	0 / 0	59%	8.50	47 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_2000233	Biological process	negative regulation of rRNA processing
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0045995	Biological process	regulation of embryonic development
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007507	Biological process	heart development
GO_0000432	Biological process	positive regulation of transcription from RNA polymerase II promoter by glucose
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0045723	Biological process	positive regulation of fatty acid biosynthetic process
GO_0090043	Biological process	regulation of tubulin deacetylation
GO_0006282	Biological process	regulation of DNA repair
GO_0060173	Biological process	limb development
GO_0018393	Biological process	internal peptidyl-lysine acetylation
GO_0071374	Biological process	cellular response to parathyroid hormone stimulus
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0018394	Biological process	peptidyl-lysine acetylation
GO_0051302	Biological process	regulation of cell division
GO_0045722	Biological process	positive regulation of gluconeogenesis
GO_0034599	Biological process	cellular response to oxidative stress
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0046600	Biological process	negative regulation of centriole replication
GO_0006094	Biological process	gluconeogenesis
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045815	Biological process	transcription initiation-coupled chromatin remodeling
GO_0007613	Biological process	memory
GO_0043484	Biological process	regulation of RNA splicing
GO_1902425	Biological process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO_0018076	Biological process	N-terminal peptidyl-lysine acetylation
GO_0010835	Biological process	regulation of protein ADP-ribosylation
GO_0042311	Biological process	vasodilation
GO_0006473	Biological process	protein acetylation
GO_0045821	Biological process	positive regulation of glycolytic process
GO_0048511	Biological process	rhythmic process
GO_0051726	Biological process	regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0072686	Cellular component	mitotic spindle
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0031674	Cellular component	I band
GO_0005829	Cellular component	cytosol
GO_0031672	Cellular component	A band
GO_0140672	Cellular component	ATAC complex
GO_0000124	Cellular component	SAGA complex
GO_0042641	Cellular component	actomyosin
GO_0005634	Cellular component	nucleus
GO_0004145	Molecular function	diamine N-acetyltransferase activity
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0004468	Molecular function	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO_0061733	Molecular function	peptide-lysine-N-acetyltransferase activity
GO_0003682	Molecular function	chromatin binding
GO_0010484	Molecular function	histone H3 acetyltransferase activity
GO_0019901	Molecular function	protein kinase binding
GO_0003712	Molecular function	transcription coregulator activity
GO_0016407	Molecular function	acetyltransferase activity
GO_0035035	Molecular function	histone acetyltransferase binding
GO_0043992	Molecular function	histone H3K9 acetyltransferase activity
GO_0004402	Molecular function	histone acetyltransferase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0004861	Molecular function	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0005515	Molecular function	protein binding
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	KAT2B
Protein name	Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
Synonyms	PCAF
Description	FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation . Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles . Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) . Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 . Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A . Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers . Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 . Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 . Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing . Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis . Also acetylates spermidine . .; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. .
Accessions	ENST00000263754.5 Q92831

KAT2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review