GSC report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GSC at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSC at tissue level.

III. Associated gene sets

GO_0030900Biological processforebrain development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007369Biological processgastrulation
GO_0021904Biological processdorsal/ventral neural tube patterning
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0048644Biological processmuscle organ morphogenesis
GO_0042474Biological processmiddle ear morphogenesis
GO_0016055Biological processWnt signaling pathway
GO_0014036Biological processneural crest cell fate specification
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding

IV. Literature review

[source]
Gene nameGSC
Protein nameHomeobox protein goosecoid
Synonyms
DescriptionFUNCTION: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. .

AccessionsENST00000238558.5
P56915