MAGEA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAGEA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAGEA3 at tissue level.

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010507Biological processnegative regulation of autophagy
GO_0010955Biological processnegative regulation of protein processing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0005783Cellular componentendoplasmic reticulum
GO_0005634Cellular componentnucleus
GO_0089720Molecular functioncaspase binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMAGEA3
Protein nameMelanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)
MAGE family member A3
SynonymsMAGE3
DescriptionFUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy . May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex . May play a role in embryonal development and tumor transformation or aspects of tumor progression . In vitro promotes cell viability in melanoma cell lines . Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes . .

AccessionsP43357
ENST00000598245.2
ENST00000417212.5
ENST00000709974.1
E7EMU0
ENST00000370278.4
ENST00000709975.1