MEPCE report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MEPCE at tissue level.

III. Associated gene sets

GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_1905382Biological processpositive regulation of snRNA transcription by RNA polymerase II
GO_0001510Biological processRNA methylation
GO_0040031Biological processsnRNA modification
GO_0016073Biological processsnRNA metabolic process
GO_1904871Biological processpositive regulation of protein localization to Cajal body
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0120259Cellular component7SK snRNP
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0008171Molecular functionO-methyltransferase activity
GO_0008173Molecular functionRNA methyltransferase activity
GO_0017069Molecular functionsnRNA binding
GO_0097322Molecular function7SK snRNA binding
GO_0005515Molecular functionprotein binding
GO_1990276Molecular functionRNA 5'-gamma-phosphate methyltransferase activity
GO_0008757Molecular functionS-adenosylmethionine-dependent methyltransferase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMEPCE
Protein nameRNA methyltransferase (EC 2.1.1.-)
7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)
SynonymsBCDIN3
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it . Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) . In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex . MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center . .

AccessionsENST00000695111.1 [Q7L2J0-2]
Q7L2J0
ENST00000695113.1
ENST00000497759.2 [Q7L2J0-2]
ENST00000414441.5 [Q7L2J0-2]
ENST00000310512.4 [Q7L2J0-1]
A0A8Q3WKJ6
ENST00000479201.2 [Q7L2J0-2]