I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| kidney distal convoluted tubule epithelial cell | 3 studies | 25% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney distal convoluted tubule epithelial cell | 3 studies | 25% ± 7% |
Insufficient scRNA-seq data for expression of HNF1B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 7060.80 | 89 / 89 | 98% | 102.37 | 886 / 901 |
| pancreas | 100% | 2615.07 | 328 / 328 | 89% | 26.42 | 159 / 178 |
| stomach | 75% | 818.42 | 269 / 359 | 91% | 17.66 | 261 / 286 |
| liver | 100% | 947.06 | 226 / 226 | 63% | 19.46 | 257 / 406 |
| lung | 96% | 767.77 | 554 / 578 | 50% | 10.26 | 580 / 1155 |
| intestine | 50% | 826.88 | 479 / 966 | 91% | 16.82 | 479 / 527 |
| prostate | 84% | 340.76 | 207 / 245 | 52% | 5.46 | 262 / 502 |
| bladder | 43% | 335.76 | 9 / 21 | 59% | 10.28 | 298 / 504 |
| esophagus | 0% | 1.87 | 6 / 1445 | 45% | 9.86 | 82 / 183 |
| uterus | 9% | 43.08 | 16 / 170 | 18% | 3.51 | 84 / 459 |
| peripheral blood | 19% | 725.80 | 176 / 929 | 0% | 0 | 0 / 0 |
| ovary | 2% | 6.53 | 4 / 180 | 14% | 1.98 | 61 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 1.51 | 2 / 29 |
| thymus | 0% | 0 | 0 / 653 | 2% | 0.27 | 13 / 605 |
| breast | 0% | 2.56 | 1 / 459 | 0% | 0.06 | 3 / 1118 |
| spleen | 0% | 0.98 | 1 / 241 | 0% | 0 | 0 / 0 |
| adipose | 0% | 1.15 | 4 / 1204 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.07 | 1 / 2642 | 0% | 0.01 | 1 / 705 |
| blood vessel | 0% | 0.33 | 2 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0 | 0 / 230 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| skin | 0% | 0 | 0 / 1809 | 0% | 0 | 0 / 472 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0060677 | Biological process | ureteric bud elongation |
| GO_0001826 | Biological process | inner cell mass cell differentiation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0031016 | Biological process | pancreas development |
| GO_0009749 | Biological process | response to glucose |
| GO_0035565 | Biological process | regulation of pronephros size |
| GO_0048754 | Biological process | branching morphogenesis of an epithelial tube |
| GO_0072095 | Biological process | regulation of branch elongation involved in ureteric bud branching |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0001822 | Biological process | kidney development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0072181 | Biological process | mesonephric duct formation |
| GO_0061017 | Biological process | hepatoblast differentiation |
| GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0048557 | Biological process | embryonic digestive tract morphogenesis |
| GO_1900212 | Biological process | negative regulation of mesenchymal cell apoptotic process involved in metanephros development |
| GO_0048793 | Biological process | pronephros development |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0030073 | Biological process | insulin secretion |
| GO_0030902 | Biological process | hindbrain development |
| GO_1900200 | Biological process | mesenchymal cell apoptotic process involved in metanephros development |
| GO_0039020 | Biological process | pronephric nephron tubule development |
| GO_0030111 | Biological process | regulation of Wnt signaling pathway |
| GO_0061296 | Biological process | negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis |
| GO_0001714 | Biological process | endodermal cell fate specification |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HNF1B |
| Protein name | HNF1 beta A splice variant 2 Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1) Hepatocyte nuclear factor 1-beta (Transcription factor 2) Hepatocyte nuclear factor 1-beta |
| Synonyms | TCF2 |
| Description | FUNCTION: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' . Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 . . |
| Accessions | ENST00000613727.4 ENST00000614313.4 ENST00000616941.3 A0A087WZC2 A0A087WXS2 A0A0C4DGS8 ENST00000633792.1 [P35680-2] ENST00000610754.4 [P35680-1] ENST00000617811.5 [P35680-1] ENST00000619478.2 E0YMJ7 E0YMJ6 ENST00000632625.1 ENST00000621123.4 [P35680-2] ENST00000614955.4 E0YMJ8 P35680 |
