SREBF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901524Biological processregulation of mitophagy
GO_0090370Biological processnegative regulation of cholesterol efflux
GO_0010886Biological processpositive regulation of cholesterol storage
GO_0008203Biological processcholesterol metabolic process
GO_0008593Biological processregulation of Notch signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0042632Biological processcholesterol homeostasis
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0032933Biological processSREBP signaling pathway
GO_1902895Biological processpositive regulation of miRNA transcription
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0071499Biological processcellular response to laminar fluid shear stress
GO_0006629Biological processlipid metabolic process
GO_0045542Biological processpositive regulation of cholesterol biosynthetic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0032937Cellular componentSREBP-SCAP-Insig complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000247Molecular functionC-8 sterol isomerase activity
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSREBF2
Protein nameSterol regulatory element-binding protein 2 (Sterol regulatory element-binding transcription factor 2)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Sterol regulatory element binding transcription factor 2
SynonymsSREBP2
hCG_41541
BHLHD2
DescriptionFUNCTION: [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane . Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis . .; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') . Regulates transcription of genes related to cholesterol synthesis pathway . .

AccessionsA0AA34QVX2
ENST00000361204.9 [Q12772-1]
G3V0I8
H0Y7E5
ENST00000424354.5
ENST00000435061.1
Q12772
ENST00000710853.1