Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 36% ± 13% | |
| oligodendrocyte | 14 studies | 39% ± 14% | |
| endothelial cell | 13 studies | 33% ± 18% | |
| glutamatergic neuron | 12 studies | 41% ± 22% | |
| oligodendrocyte precursor cell | 12 studies | 43% ± 14% | |
| type I pneumocyte | 11 studies | 31% ± 15% | |
| microglial cell | 9 studies | 30% ± 7% | |
| B cell | 9 studies | 24% ± 5% | |
| adipocyte | 9 studies | 30% ± 11% | |
| ciliated cell | 9 studies | 27% ± 11% | |
| GABAergic neuron | 8 studies | 45% ± 20% | |
| epithelial cell | 8 studies | 37% ± 19% | |
| basal cell | 8 studies | 29% ± 13% | |
| macrophage | 7 studies | 33% ± 15% | |
| retinal ganglion cell | 7 studies | 48% ± 15% | |
| fibroblast | 7 studies | 23% ± 9% | |
| type II pneumocyte | 7 studies | 39% ± 12% | |
| neuron | 6 studies | 46% ± 12% | |
| interneuron | 6 studies | 40% ± 20% | |
| dendritic cell | 6 studies | 21% ± 7% | |
| club cell | 6 studies | 38% ± 17% | |
| pericyte | 5 studies | 31% ± 13% | |
| memory B cell | 5 studies | 17% ± 1% | |
| cardiac muscle cell | 5 studies | 27% ± 6% | |
| retina horizontal cell | 5 studies | 27% ± 9% | |
| smooth muscle cell | 5 studies | 19% ± 3% | |
| goblet cell | 5 studies | 36% ± 28% | |
| granule cell | 4 studies | 36% ± 4% | |
| plasma cell | 4 studies | 29% ± 2% | |
| retinal pigment epithelial cell | 4 studies | 39% ± 14% | |
| endothelial cell of lymphatic vessel | 4 studies | 22% ± 5% | |
| hepatocyte | 4 studies | 53% ± 20% | |
| monocyte | 4 studies | 29% ± 9% | |
| myeloid cell | 4 studies | 27% ± 6% | |
| respiratory goblet cell | 4 studies | 43% ± 16% | |
| ionocyte | 3 studies | 33% ± 7% | |
| classical monocyte | 3 studies | 18% ± 3% | |
| hematopoietic precursor cell | 3 studies | 37% ± 23% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 42% ± 6% | |
| GABAergic interneuron | 3 studies | 33% ± 12% | |
| progenitor cell | 3 studies | 29% ± 8% | |
| naive B cell | 3 studies | 17% ± 1% | |
| GABAergic amacrine cell | 3 studies | 37% ± 14% | |
| Mueller cell | 3 studies | 17% ± 2% | |
| retinal cone cell | 3 studies | 20% ± 3% | |
| amacrine cell | 3 studies | 31% ± 11% | |
| neural progenitor cell | 3 studies | 36% ± 14% | |
| ependymal cell | 3 studies | 30% ± 10% | |
| mast cell | 3 studies | 27% ± 8% | |
| T cell | 3 studies | 23% ± 7% | |
| alveolar macrophage | 3 studies | 18% ± 3% | |
| natural killer cell | 3 studies | 18% ± 2% | |
| lymphocyte | 3 studies | 32% ± 11% | |
| transit amplifying cell | 3 studies | 35% ± 25% | |
| mucus secreting cell | 3 studies | 40% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 13746.76 | 1445 / 1445 | 100% | 137.31 | 183 / 183 |
| stomach | 100% | 11255.13 | 359 / 359 | 100% | 98.87 | 286 / 286 |
| intestine | 100% | 10192.33 | 966 / 966 | 100% | 104.11 | 526 / 527 |
| prostate | 100% | 8318.58 | 245 / 245 | 100% | 96.42 | 500 / 502 |
| uterus | 100% | 8833.06 | 170 / 170 | 100% | 88.43 | 457 / 459 |
| skin | 100% | 13210.32 | 1809 / 1809 | 99% | 108.90 | 469 / 472 |
| brain | 100% | 15516.72 | 2634 / 2642 | 100% | 112.94 | 702 / 705 |
| bladder | 100% | 8181.19 | 21 / 21 | 99% | 76.78 | 498 / 504 |
| lung | 99% | 11048.60 | 575 / 578 | 99% | 101.93 | 1145 / 1155 |
| breast | 100% | 6014.66 | 457 / 459 | 99% | 80.18 | 1104 / 1118 |
| thymus | 100% | 6973.38 | 650 / 653 | 98% | 51.49 | 592 / 605 |
| pancreas | 98% | 6493.07 | 321 / 328 | 99% | 74.25 | 176 / 178 |
| adrenal gland | 100% | 21845.02 | 258 / 258 | 96% | 90.18 | 221 / 230 |
| liver | 99% | 6736.26 | 223 / 226 | 96% | 65.85 | 390 / 406 |
| ovary | 100% | 9162.09 | 180 / 180 | 94% | 48.89 | 403 / 430 |
| kidney | 100% | 7846.79 | 89 / 89 | 92% | 41.61 | 829 / 901 |
| eye | 0% | 0 | 0 / 0 | 100% | 67.97 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 74.97 | 29 / 29 |
| spleen | 100% | 7787.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 137.18 | 45 / 45 |
| adipose | 100% | 5979.43 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 7583.15 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 98% | 5015.44 | 788 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 7922.84 | 823 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 72% | 7893.98 | 671 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901524 | Biological process | regulation of mitophagy |
| GO_0090370 | Biological process | negative regulation of cholesterol efflux |
| GO_0010886 | Biological process | positive regulation of cholesterol storage |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0008593 | Biological process | regulation of Notch signaling pathway |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0009267 | Biological process | cellular response to starvation |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0071404 | Biological process | cellular response to low-density lipoprotein particle stimulus |
| GO_0032933 | Biological process | SREBP signaling pathway |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_1903955 | Biological process | positive regulation of protein targeting to mitochondrion |
| GO_0071499 | Biological process | cellular response to laminar fluid shear stress |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0045542 | Biological process | positive regulation of cholesterol biosynthetic process |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0012507 | Cellular component | ER to Golgi transport vesicle membrane |
| GO_0032937 | Cellular component | SREBP-SCAP-Insig complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0000247 | Molecular function | C-8 sterol isomerase activity |
| GO_0070888 | Molecular function | E-box binding |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SREBF2 |
| Protein name | Sterol regulatory element-binding protein 2 (Sterol regulatory element-binding transcription factor 2) Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] Sterol regulatory element binding transcription factor 2 |
| Synonyms | SREBP2 hCG_41541 BHLHD2 |
| Description | FUNCTION: [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane . Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis . .; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') . Regulates transcription of genes related to cholesterol synthesis pathway . . |
| Accessions | A0AA34QVX2 ENST00000361204.9 [Q12772-1] G3V0I8 H0Y7E5 ENST00000424354.5 ENST00000435061.1 Q12772 ENST00000710853.1 |