CBX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CBX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBX2 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045137Biological processdevelopment of primary sexual characteristics
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031519Cellular componentPcG protein complex
GO_0000792Cellular componentheterochromatin
GO_0000791Cellular componenteuchromatin
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0035064Molecular functionmethylated histone binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameCBX2
Protein nameChromobox protein homolog 2
Synonyms
DescriptionFUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression . .

AccessionsQ14781
ENST00000310942.9 [Q14781-1]
ENST00000269399.5 [Q14781-2]