Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 18 studies | 27% ± 10% | |
| endothelial cell of lymphatic vessel | 14 studies | 30% ± 8% | |
| glutamatergic neuron | 10 studies | 37% ± 18% | |
| capillary endothelial cell | 4 studies | 25% ± 8% | |
| endothelial cell of vascular tree | 4 studies | 23% ± 7% | |
| GABAergic neuron | 4 studies | 36% ± 13% | |
| interneuron | 4 studies | 23% ± 7% | |
| glomerular endothelial cell | 3 studies | 23% ± 3% | |
| vein endothelial cell | 3 studies | 26% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 33% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 6394.26 | 257 / 258 | 92% | 46.52 | 212 / 230 |
| thymus | 97% | 3937.92 | 635 / 653 | 89% | 7.02 | 538 / 605 |
| prostate | 93% | 3297.46 | 228 / 245 | 84% | 4.56 | 421 / 502 |
| brain | 73% | 8182.62 | 1927 / 2642 | 97% | 31.37 | 683 / 705 |
| breast | 100% | 12933.70 | 459 / 459 | 66% | 3.64 | 739 / 1118 |
| kidney | 94% | 4009.30 | 84 / 89 | 70% | 10.81 | 633 / 901 |
| bladder | 100% | 4513.48 | 21 / 21 | 37% | 1.96 | 184 / 504 |
| esophagus | 83% | 3093.48 | 1199 / 1445 | 51% | 2.42 | 94 / 183 |
| uterus | 99% | 6214.97 | 168 / 170 | 29% | 1.38 | 133 / 459 |
| intestine | 89% | 4149.84 | 863 / 966 | 27% | 1.13 | 143 / 527 |
| lung | 71% | 1690.05 | 411 / 578 | 44% | 1.90 | 505 / 1155 |
| adipose | 100% | 13745.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 30340.42 | 241 / 241 | 0% | 0 | 0 / 0 |
| skin | 56% | 1699.68 | 1004 / 1809 | 44% | 2.22 | 209 / 472 |
| liver | 35% | 821.06 | 80 / 226 | 61% | 2.72 | 248 / 406 |
| stomach | 56% | 1954.07 | 201 / 359 | 40% | 1.99 | 113 / 286 |
| heart | 93% | 3391.88 | 803 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 5% | 96.27 | 17 / 328 | 77% | 4.50 | 137 / 178 |
| ovary | 42% | 1296.99 | 76 / 180 | 17% | 0.67 | 71 / 430 |
| blood vessel | 54% | 1739.07 | 719 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 50% | 1005.42 | 399 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 0.65 | 10 / 45 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.54 | 16 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.35 | 4 / 29 |
| peripheral blood | 0% | 10.05 | 4 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019934 | Biological process | cGMP-mediated signaling |
| GO_0010752 | Biological process | regulation of cGMP-mediated signaling |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0035904 | Biological process | aorta development |
| GO_0010821 | Biological process | regulation of mitochondrion organization |
| GO_0043117 | Biological process | positive regulation of vascular permeability |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_1904613 | Biological process | cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| GO_0046069 | Biological process | cGMP catabolic process |
| GO_0043116 | Biological process | negative regulation of vascular permeability |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0010754 | Biological process | negative regulation of cGMP-mediated signaling |
| GO_0071321 | Biological process | cellular response to cGMP |
| GO_0003281 | Biological process | ventricular septum development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0036006 | Biological process | cellular response to macrophage colony-stimulating factor stimulus |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0003170 | Biological process | heart valve development |
| GO_0043949 | Biological process | regulation of cAMP-mediated signaling |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0043951 | Biological process | negative regulation of cAMP-mediated signaling |
| GO_0106072 | Biological process | negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0097060 | Cellular component | synaptic membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0030911 | Molecular function | TPR domain binding |
| GO_0030552 | Molecular function | cAMP binding |
| GO_0030553 | Molecular function | cGMP binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0047555 | Molecular function | 3',5'-cyclic-GMP phosphodiesterase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004115 | Molecular function | 3',5'-cyclic-AMP phosphodiesterase activity |
| GO_0042301 | Molecular function | phosphate ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004118 | Molecular function | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity |
| Gene name | PDE2A |
| Protein name | Phosphodiesterase 2A Alternative protein PDE2A Phosphodiesterase (EC 3.1.4.-) cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) |
| Synonyms | |
| Description | FUNCTION: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a higher efficiency with cGMP compared to cAMP . Plays a role in cell growth and migration . .; FUNCTION: [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L . . |
| Accessions | Q8IW54 ENST00000539367.5 F5GXX2 H7C009 ENST00000536308.5 ENST00000546038.1 ENST00000540345.5 [O00408-4] ENST00000376450.7 [O00408-5] ENST00000544570.5 [O00408-3] ENST00000444035.6 [O00408-2] L8E8Y0 H0YG13 ENST00000536458.1 ENST00000543750.5 ENST00000538299.1 ENST00000542223.1 H0YFL1 F5H3Z7 ENST00000543575.5 F5H130 ENST00000537631.5 E9PEF1 ENST00000535701.1 ENST00000418754.6 F5H5P8 O00408 F5H2R8 ENST00000475807.6 F5H1D7 F5H2Z0 ENST00000538749.5 ENST00000441209.6 ENST00000542969.2 C9JPD5 ENST00000420501.5 ENST00000334456.10 [O00408-1] ENST00000541998.5 F5H2V7 H0YGL2 F5H143 |
