SINHCAF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	27 studies	24% ± 7%	Explore
memory B cell	16 studies	23% ± 5%	Explore
epithelial cell	14 studies	36% ± 19%	Explore
ciliated cell	13 studies	33% ± 14%	Explore
plasmacytoid dendritic cell	13 studies	33% ± 9%	Explore
endothelial cell	12 studies	24% ± 7%	Explore
basal cell	10 studies	31% ± 14%	Explore
naive B cell	9 studies	22% ± 6%	Explore
dendritic cell	7 studies	44% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 4%	Explore
precursor B cell	6 studies	36% ± 11%	Explore
endothelial cell of vascular tree	6 studies	21% ± 4%	Explore
natural killer cell	5 studies	22% ± 6%	Explore
hematopoietic precursor cell	5 studies	32% ± 17%	Explore
CD4-positive, alpha-beta T cell	5 studies	27% ± 6%	Explore
T follicular helper cell	5 studies	17% ± 2%	Explore
abnormal cell	4 studies	31% ± 6%	Explore
smooth muscle cell	4 studies	21% ± 4%	Explore
immature B cell	4 studies	32% ± 14%	Explore
pro-B cell	4 studies	38% ± 5%	Explore
CD8-positive, alpha-beta T cell	4 studies	21% ± 6%	Explore
hematopoietic stem cell	4 studies	27% ± 12%	Explore
enteroendocrine cell	4 studies	25% ± 10%	Explore
goblet cell	4 studies	28% ± 8%	Explore
regulatory T cell	4 studies	20% ± 5%	Explore
secretory cell	4 studies	36% ± 11%	Explore
T cell	3 studies	38% ± 19%	Explore
type I pneumocyte	3 studies	19% ± 4%	Explore
conventional dendritic cell	3 studies	34% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore
connective tissue cell	3 studies	37% ± 23%	Explore
progenitor cell	3 studies	23% ± 5%	Explore
vein endothelial cell	3 studies	28% ± 14%	Explore
capillary endothelial cell	3 studies	21% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	29% ± 15%	Explore
peripheral blood	3 studies	28% ± 9%	Explore
bone marrow	3 studies	21% ± 4%	Explore
intestine	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	2885.04	180 / 180	100%	96.18	430 / 430
esophagus	100%	1486.64	1442 / 1445	100%	53.34	183 / 183
stomach	100%	1071.69	358 / 359	99%	47.48	283 / 286
intestine	100%	1744.25	965 / 966	99%	52.40	520 / 527
lung	100%	1827.23	577 / 578	99%	51.09	1139 / 1155
pancreas	99%	1294.19	326 / 328	96%	29.22	171 / 178
bladder	100%	1784.10	21 / 21	95%	40.02	478 / 504
prostate	100%	2417.75	245 / 245	92%	26.84	464 / 502
uterus	100%	4573.08	170 / 170	92%	32.87	421 / 459
thymus	100%	1429.69	653 / 653	90%	21.87	543 / 605
breast	100%	2043.58	457 / 459	90%	32.09	1004 / 1118
kidney	100%	2229.90	89 / 89	89%	25.18	803 / 901
skin	100%	2121.64	1808 / 1809	81%	21.58	381 / 472
adrenal gland	100%	1143.86	258 / 258	38%	6.44	87 / 230
spleen	100%	1711.03	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	10.05	1 / 1
adipose	100%	1528.41	1203 / 1204	0%	0	0 / 0
blood vessel	96%	690.60	1275 / 1335	0%	0	0 / 0
brain	26%	123.24	695 / 2642	68%	11.62	476 / 705
tonsil	0%	0	0 / 0	91%	31.11	41 / 45
lymph node	0%	0	0 / 0	90%	28.54	26 / 29
peripheral blood	82%	2382.20	759 / 929	0%	0	0 / 0
heart	75%	466.84	649 / 861	0%	0	0 / 0
liver	43%	222.31	97 / 226	26%	5.59	106 / 406
eye	0%	0	0 / 0	44%	6.55	35 / 80
muscle	19%	87.03	156 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045596	Biological process	negative regulation of cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030336	Biological process	negative regulation of cell migration
GO_1902455	Biological process	negative regulation of stem cell population maintenance
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0070822	Cellular component	Sin3-type complex
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SINHCAF
Protein name	SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog) SIN3-HDAC complex-associated factor
Synonyms	FAM60A C12orf14 L4
Description	FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway . Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). .
Accessions	ENST00000632726.1 ENST00000633702.1 [Q9NP50-1] ENST00000631546.1 ENST00000543615.1 ENST00000337682.9 [Q9NP50-1] ENST00000542983.1 [Q9NP50-2] ENST00000454658.6 [Q9NP50-1] F5GZ82 Q9NP50 ENST00000539004.5 F5H6U2 H0YGG0 ENST00000617411.2 [Q9NP50-1] ENST00000539409.5 [Q9NP50-2] ENST00000633815.1 [Q9NP50-2] ENST00000632259.1 ENST00000631598.1 [Q9NP50-2] ENST00000544921.5

SINHCAF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review