ZBTB33 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZBTB33 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZBTB33 at tissue level.

III. Associated gene sets

GO_0002682Biological processregulation of immune system process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035556Biological processintracellular signal transduction
GO_0001817Biological processregulation of cytokine production
GO_0016055Biological processWnt signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0008327Molecular functionmethyl-CpG binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZBTB33
Protein nameAlternative protein ZBTB33
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
SynonymsKAISO
ZNF348
DescriptionFUNCTION: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 . .

AccessionsENST00000326624.2
ENST00000557385.2
Q86T24
L8E7W8