Insufficient scRNA-seq data for expression of FOXH1 at single-cell level.
Insufficient scRNA-seq data for expression of FOXH1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 84% | 18.03 | 301 / 359 | 27% | 1.15 | 77 / 286 |
bladder | 81% | 13.29 | 17 / 21 | 26% | 1.13 | 132 / 504 |
ovary | 59% | 3.38 | 106 / 180 | 47% | 2.81 | 203 / 430 |
intestine | 78% | 40.79 | 751 / 966 | 24% | 0.99 | 128 / 527 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.07 | 1 / 1 |
breast | 91% | 13.00 | 417 / 459 | 7% | 0.15 | 83 / 1118 |
prostate | 96% | 21.70 | 234 / 245 | 1% | 0.02 | 6 / 502 |
spleen | 97% | 13.34 | 233 / 241 | 0% | 0 | 0 / 0 |
kidney | 96% | 13.43 | 85 / 89 | 1% | 0.04 | 8 / 901 |
skin | 93% | 12.15 | 1679 / 1809 | 1% | 0.02 | 7 / 472 |
pancreas | 69% | 4.85 | 226 / 328 | 24% | 0.66 | 42 / 178 |
thymus | 92% | 10.31 | 598 / 653 | 0% | 0.00 | 1 / 605 |
lung | 78% | 6.78 | 450 / 578 | 12% | 0.85 | 137 / 1155 |
adrenal gland | 86% | 8.33 | 222 / 258 | 0% | 0.01 | 1 / 230 |
brain | 86% | 12.49 | 2277 / 2642 | 0% | 0.00 | 1 / 705 |
liver | 84% | 8.62 | 189 / 226 | 2% | 0.43 | 7 / 406 |
adipose | 75% | 6.90 | 907 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 58% | 6.12 | 838 / 1445 | 17% | 0.79 | 31 / 183 |
uterus | 67% | 4.20 | 114 / 170 | 7% | 0.20 | 32 / 459 |
blood vessel | 39% | 2.22 | 514 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 36% | 2.92 | 331 / 929 | 0% | 0 | 0 / 0 |
muscle | 25% | 1.18 | 202 / 803 | 0% | 0 | 0 / 0 |
heart | 25% | 1.21 | 212 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.18 | 1 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0003151 | Biological process | outflow tract morphogenesis |
GO_0035054 | Biological process | embryonic heart tube anterior/posterior pattern specification |
GO_0001947 | Biological process | heart looping |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_0033147 | Biological process | negative regulation of intracellular estrogen receptor signaling pathway |
GO_0071345 | Biological process | cellular response to cytokine stimulus |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0035909 | Biological process | aorta morphogenesis |
GO_0060766 | Biological process | negative regulation of androgen receptor signaling pathway |
GO_0038092 | Biological process | nodal signaling pathway |
GO_0003140 | Biological process | determination of left/right asymmetry in lateral mesoderm |
GO_0048318 | Biological process | axial mesoderm development |
GO_0003139 | Biological process | secondary heart field specification |
GO_0003222 | Biological process | ventricular trabecula myocardium morphogenesis |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_0070365 | Biological process | hepatocyte differentiation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
GO_0005634 | Cellular component | nucleus |
GO_0032444 | Cellular component | activin responsive factor complex |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0003677 | Molecular function | DNA binding |
GO_0070412 | Molecular function | R-SMAD binding |
GO_0140297 | Molecular function | DNA-binding transcription factor binding |
GO_0043425 | Molecular function | bHLH transcription factor binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_0046332 | Molecular function | SMAD binding |
GO_0070410 | Molecular function | co-SMAD binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0050681 | Molecular function | nuclear androgen receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FOXH1 |
Protein name | FOXH1 protein Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2) |
Synonyms | FAST2 FAST1 |
Description | FUNCTION: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). . |
Accessions | Q6P0Y2 O75593 ENST00000377317.5 |