CREM | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	35 studies	37% ± 18%	Explore
natural killer cell	34 studies	36% ± 16%	Explore
CD8-positive, alpha-beta T cell	31 studies	31% ± 13%	Explore
endothelial cell	31 studies	31% ± 16%	Explore
CD4-positive, alpha-beta T cell	27 studies	31% ± 12%	Explore
T cell	25 studies	38% ± 20%	Explore
regulatory T cell	21 studies	40% ± 16%	Explore
mast cell	20 studies	41% ± 19%	Explore
B cell	17 studies	32% ± 15%	Explore
conventional dendritic cell	17 studies	34% ± 12%	Explore
smooth muscle cell	17 studies	35% ± 18%	Explore
pericyte	15 studies	36% ± 19%	Explore
fibroblast	14 studies	31% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	30% ± 11%	Explore
dendritic cell	12 studies	34% ± 11%	Explore
monocyte	12 studies	30% ± 15%	Explore
endothelial cell of lymphatic vessel	12 studies	26% ± 9%	Explore
myeloid cell	12 studies	38% ± 15%	Explore
mature NK T cell	11 studies	38% ± 15%	Explore
gamma-delta T cell	11 studies	40% ± 20%	Explore
oligodendrocyte precursor cell	11 studies	38% ± 16%	Explore
astrocyte	11 studies	28% ± 10%	Explore
endothelial cell of vascular tree	11 studies	28% ± 10%	Explore
plasmacytoid dendritic cell	10 studies	41% ± 21%	Explore
leukocyte	9 studies	40% ± 16%	Explore
classical monocyte	9 studies	36% ± 17%	Explore
connective tissue cell	9 studies	29% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	34% ± 16%	Explore
mucosal invariant T cell	8 studies	39% ± 11%	Explore
innate lymphoid cell	8 studies	39% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	31% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	42% ± 20%	Explore
naive B cell	7 studies	29% ± 10%	Explore
microglial cell	7 studies	23% ± 4%	Explore
memory B cell	7 studies	29% ± 11%	Explore
non-classical monocyte	7 studies	32% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	36% ± 12%	Explore
mononuclear phagocyte	6 studies	38% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	40% ± 25%	Explore
myofibroblast cell	6 studies	24% ± 10%	Explore
epithelial cell	6 studies	30% ± 8%	Explore
neutrophil	5 studies	24% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	38% ± 23%	Explore
cardiac muscle cell	5 studies	20% ± 2%	Explore
ciliated cell	5 studies	24% ± 5%	Explore
T follicular helper cell	5 studies	37% ± 16%	Explore
CD4-positive helper T cell	5 studies	54% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	40% ± 25%	Explore
endothelial cell of artery	4 studies	26% ± 10%	Explore
capillary endothelial cell	4 studies	19% ± 2%	Explore
retinal pigment epithelial cell	4 studies	30% ± 12%	Explore
granulocyte	4 studies	45% ± 23%	Explore
group 3 innate lymphoid cell	4 studies	42% ± 10%	Explore
T-helper 17 cell	4 studies	45% ± 21%	Explore
oligodendrocyte	4 studies	21% ± 6%	Explore
pancreatic A cell	3 studies	25% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	32% ± 12%	Explore
tissue-resident macrophage	3 studies	40% ± 13%	Explore
lymphocyte	3 studies	32% ± 12%	Explore
Mueller cell	3 studies	23% ± 4%	Explore
exhausted T cell	3 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	49% ± 19%	Explore
monocyte-derived dendritic cell	3 studies	43% ± 21%	Explore
muscle cell	3 studies	29% ± 3%	Explore
GABAergic neuron	3 studies	42% ± 9%	Explore
glutamatergic neuron	3 studies	55% ± 8%	Explore
basal cell	3 studies	24% ± 2%	Explore
neuron	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	26% ± 12%	Explore
brain	8 studies	31% ± 11%	Explore
uterus	5 studies	35% ± 7%	Explore
pancreas	4 studies	21% ± 4%	Explore
peripheral blood	4 studies	23% ± 5%	Explore
intestine	4 studies	27% ± 6%	Explore
kidney	4 studies	25% ± 4%	Explore
eye	4 studies	25% ± 6%	Explore
liver	4 studies	33% ± 15%	Explore
adrenal gland	3 studies	35% ± 13%	Explore
prostate	3 studies	24% ± 7%	Explore
breast	3 studies	25% ± 3%	Explore
lymph node	3 studies	34% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	3642.71	180 / 180	100%	11.67	429 / 430
breast	100%	1666.90	459 / 459	100%	12.69	1115 / 1118
brain	100%	1619.71	2638 / 2642	100%	15.98	704 / 705
adrenal gland	100%	5526.86	258 / 258	100%	27.17	229 / 230
uterus	99%	1660.06	169 / 170	100%	13.08	459 / 459
prostate	100%	2200.12	244 / 245	100%	11.88	501 / 502
lung	99%	1997.54	575 / 578	100%	12.50	1153 / 1155
thymus	100%	1414.72	651 / 653	100%	11.98	602 / 605
kidney	100%	1781.79	89 / 89	98%	14.83	887 / 901
bladder	100%	1304.76	21 / 21	98%	10.96	496 / 504
liver	99%	1234.83	223 / 226	100%	11.21	404 / 406
intestine	99%	1257.34	959 / 966	97%	8.10	513 / 527
esophagus	97%	1046.18	1397 / 1445	99%	9.31	181 / 183
stomach	96%	993.65	345 / 359	98%	8.44	279 / 286
skin	92%	607.29	1658 / 1809	96%	14.25	455 / 472
pancreas	85%	526.14	278 / 328	99%	13.10	177 / 178
lymph node	0%	0	0 / 0	100%	15.40	29 / 29
spleen	100%	1676.93	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.30	45 / 45
ureter	0%	0	0 / 0	100%	5.22	1 / 1
adipose	100%	2272.59	1202 / 1204	0%	0	0 / 0
blood vessel	100%	1801.18	1332 / 1335	0%	0	0 / 0
muscle	99%	1045.89	793 / 803	0%	0	0 / 0
heart	97%	1551.65	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	8.63	67 / 80
peripheral blood	78%	1473.47	720 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006687	Biological process	glycosphingolipid metabolic process
GO_0007283	Biological process	spermatogenesis
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007165	Biological process	signal transduction
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030154	Biological process	cell differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0048511	Biological process	rhythmic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_1990589	Cellular component	ATF4-CREB1 transcription factor complex
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0005515	Molecular function	protein binding
GO_0008140	Molecular function	cAMP response element binding protein binding

IV. Literature review

[source]

Gene name	CREM
Protein name	cAMP responsive element modulator cAMP responsive element moderator cAMP-responsive element modulator cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)
Synonyms
Description	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation . .; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. .
Accessions	ENST00000374721.7 R4GN75 ENST00000473940.5 [Q03060-8] C9IYM9 ENST00000463960.5 F8WB03 ENST00000495960.5 ENST00000490460.5 ENST00000395887.8 [Q03060-22] ENST00000356917.9 [Q03060-9] ENST00000348787.6 [Q03060-30] F8WDF2 ENST00000495301.1 Q9BYY5 ENST00000484283.5 Q03060 A0A0A0MSU8 ENST00000488741.5 [Q03060-23] ENST00000479070.5 [Q03060-15] ENST00000427847.6 E9PB41 ENST00000487132.6 C9J2J0 H7C4X0 ENST00000345491.7 [Q03060-16] J3KR46 ENST00000686585.1 [Q03060-16] ENST00000469949.6 ENST00000490511.1 [Q03060-27] ENST00000487763.5 [Q03060-10] ENST00000374726.7 [Q03060-25] ENST00000489321.5 [Q03060-25] ENST00000463314.5 [Q03060-28] ENST00000474362.5 ENST00000474931.5 [Q03060-24] ENST00000354759.7 [Q03060-26] ENST00000494479.5 ENST00000374734.7 [Q03060-32] C9K092 ENST00000487132.6 [Q03060-30] ENST00000429130.7 [Q03060-5] ENST00000468236.5 [Q03060-29] ENST00000361599.8 [Q03060-12] ENST00000344351.5 G5E998 ENST00000464475.1 ENST00000342105.7 [Q03060-7] ENST00000488328.5 [Q03060-11] C9J5A7 ENST00000337656.8 [Q03060-31] E9PAR2 ENST00000685392.1 [Q03060-31] ENST00000460270.5

CREM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review