Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 5 studies | 59% ± 10% | |
| fibroblast | 4 studies | 25% ± 2% | |
| endocardial cell | 3 studies | 38% ± 6% | |
| smooth muscle cell | 3 studies | 23% ± 4% | |
| endothelial cell | 3 studies | 32% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 4 studies | 30% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2373.67 | 226 / 226 | 98% | 21.58 | 399 / 406 |
| pancreas | 100% | 3592.24 | 328 / 328 | 79% | 12.82 | 141 / 178 |
| stomach | 78% | 3086.86 | 279 / 359 | 57% | 45.40 | 163 / 286 |
| ovary | 98% | 11782.25 | 176 / 180 | 34% | 4.95 | 147 / 430 |
| heart | 99% | 7255.70 | 855 / 861 | 0% | 0 | 0 / 0 |
| esophagus | 13% | 335.59 | 191 / 1445 | 58% | 34.98 | 106 / 183 |
| skin | 0% | 0.83 | 2 / 1809 | 38% | 6.69 | 177 / 472 |
| intestine | 1% | 27.43 | 8 / 966 | 31% | 10.62 | 166 / 527 |
| eye | 0% | 0 | 0 / 0 | 30% | 3.93 | 24 / 80 |
| lung | 0% | 16.45 | 2 / 578 | 22% | 8.47 | 257 / 1155 |
| adrenal gland | 5% | 37.51 | 13 / 258 | 15% | 3.78 | 35 / 230 |
| blood vessel | 18% | 685.52 | 245 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 3% | 29.39 | 5 / 170 | 12% | 1.38 | 56 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 1.05 | 4 / 29 |
| breast | 0% | 2.27 | 1 / 459 | 9% | 1.22 | 105 / 1118 |
| bladder | 0% | 0 | 0 / 21 | 10% | 0.89 | 48 / 504 |
| brain | 0% | 0 | 0 / 2642 | 7% | 0.86 | 48 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.32 | 2 / 45 |
| kidney | 0% | 0 | 0 / 89 | 2% | 0.27 | 20 / 901 |
| prostate | 0% | 4.10 | 1 / 245 | 1% | 0.03 | 3 / 502 |
| adipose | 0% | 4.44 | 4 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 2.39 | 3 / 929 | 0% | 0 | 0 / 0 |
| thymus | 0% | 1.15 | 1 / 653 | 0% | 0 | 0 / 605 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_0003190 | Biological process | atrioventricular valve formation |
| GO_0035054 | Biological process | embryonic heart tube anterior/posterior pattern specification |
| GO_0061049 | Biological process | cell growth involved in cardiac muscle cell development |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0001947 | Biological process | heart looping |
| GO_0086004 | Biological process | regulation of cardiac muscle cell contraction |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_1902176 | Biological process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| GO_0033189 | Biological process | response to vitamin A |
| GO_0003281 | Biological process | ventricular septum development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0003215 | Biological process | cardiac right ventricle morphogenesis |
| GO_0061026 | Biological process | cardiac muscle tissue regeneration |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0003208 | Biological process | cardiac ventricle morphogenesis |
| GO_0042060 | Biological process | wound healing |
| GO_0007492 | Biological process | endoderm development |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0003290 | Biological process | atrial septum secundum morphogenesis |
| GO_0003197 | Biological process | endocardial cushion development |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0010575 | Biological process | positive regulation of vascular endothelial growth factor production |
| GO_0036302 | Biological process | atrioventricular canal development |
| GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0008584 | Biological process | male gonad development |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0003289 | Biological process | atrial septum primum morphogenesis |
| GO_0010667 | Biological process | negative regulation of cardiac muscle cell apoptotic process |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0060290 | Biological process | transdifferentiation |
| GO_0003162 | Biological process | atrioventricular node development |
| GO_0060575 | Biological process | intestinal epithelial cell differentiation |
| GO_0048617 | Biological process | embryonic foregut morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0016604 | Cellular component | nuclear body |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0070410 | Molecular function | co-SMAD binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0051525 | Molecular function | NFAT protein binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0001216 | Molecular function | DNA-binding transcription activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GATA4 |
| Protein name | GATA binding protein 4 (cDNA FLJ39741 fis, clone SMINT2016544, highly similar to TRANSCRIPTION FACTOR GATA-4) Transcription factor GATA-4 (GATA-binding factor 4) GATA binding protein 4 |
| Synonyms | |
| Description | FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function . In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression . Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement . Required during testicular development . May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase . . |
| Accessions | ENST00000528712.5 B0LXF4 B0LXF6 B2ZBW2 B0LXF3 B0LXF2 B3KUF4 B6DU75 P43694 B2ZBW1 B0LXE8 ENST00000532977.1 ENST00000622443.3 [P43694-1] B0LXF5 A0A087WZ09 ENST00000622443 B0LXF1 ENST00000526716.5 ENST00000526974.1 R4GND5 ENST00000647274.1 [P43694-1] A9Z1I4 B0LXF0 ENST00000643249.3 [P43694-2] ENST00000532059.6 [P43694-2] B0LXE9 ENST00000335135.8 [P43694-1] E9PKS4 |
