CCND3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	44 studies	54% ± 16%	Explore
B cell	37 studies	39% ± 13%	Explore
endothelial cell	35 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	35 studies	47% ± 16%	Explore
CD4-positive, alpha-beta T cell	34 studies	47% ± 16%	Explore
T cell	32 studies	43% ± 14%	Explore
regulatory T cell	27 studies	42% ± 16%	Explore
non-classical monocyte	22 studies	38% ± 15%	Explore
mature NK T cell	21 studies	50% ± 14%	Explore
monocyte	19 studies	29% ± 12%	Explore
conventional dendritic cell	18 studies	35% ± 19%	Explore
gamma-delta T cell	18 studies	45% ± 16%	Explore
memory B cell	18 studies	32% ± 8%	Explore
naive B cell	18 studies	35% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	49% ± 18%	Explore
macrophage	18 studies	28% ± 14%	Explore
classical monocyte	17 studies	33% ± 15%	Explore
mucosal invariant T cell	16 studies	51% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	66% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	57% ± 14%	Explore
plasmacytoid dendritic cell	15 studies	39% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	51% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	56% ± 13%	Explore
dendritic cell	13 studies	34% ± 16%	Explore
mast cell	13 studies	34% ± 14%	Explore
type I pneumocyte	12 studies	35% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	47% ± 16%	Explore
capillary endothelial cell	12 studies	28% ± 10%	Explore
platelet	11 studies	54% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	48% ± 14%	Explore
pericyte	11 studies	21% ± 3%	Explore
microglial cell	11 studies	36% ± 16%	Explore
fibroblast	11 studies	26% ± 8%	Explore
innate lymphoid cell	10 studies	51% ± 22%	Explore
type II pneumocyte	10 studies	39% ± 17%	Explore
vein endothelial cell	10 studies	28% ± 13%	Explore
basal cell	10 studies	28% ± 12%	Explore
endothelial cell of lymphatic vessel	10 studies	27% ± 7%	Explore
leukocyte	9 studies	38% ± 24%	Explore
endothelial cell of artery	9 studies	24% ± 8%	Explore
glutamatergic neuron	8 studies	30% ± 15%	Explore
endothelial cell of vascular tree	8 studies	30% ± 6%	Explore
myeloid cell	8 studies	33% ± 13%	Explore
precursor B cell	7 studies	47% ± 13%	Explore
T follicular helper cell	7 studies	48% ± 13%	Explore
astrocyte	7 studies	34% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	55% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	54% ± 22%	Explore
megakaryocyte	6 studies	71% ± 23%	Explore
hematopoietic stem cell	6 studies	32% ± 21%	Explore
plasma cell	6 studies	29% ± 8%	Explore
epithelial cell	6 studies	37% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	52% ± 22%	Explore
ciliated cell	6 studies	22% ± 4%	Explore
club cell	6 studies	36% ± 9%	Explore
CD4-positive helper T cell	5 studies	28% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	44% ± 16%	Explore
hematopoietic precursor cell	5 studies	32% ± 15%	Explore
exhausted T cell	5 studies	48% ± 16%	Explore
smooth muscle cell	5 studies	19% ± 3%	Explore
lymphocyte	5 studies	66% ± 20%	Explore
pro-B cell	5 studies	58% ± 10%	Explore
myofibroblast cell	5 studies	23% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	47% ± 18%	Explore
plasmablast	4 studies	42% ± 21%	Explore
GABAergic neuron	4 studies	30% ± 10%	Explore
mononuclear phagocyte	4 studies	34% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	64% ± 5%	Explore
abnormal cell	4 studies	37% ± 25%	Explore
respiratory goblet cell	4 studies	33% ± 13%	Explore
alveolar macrophage	4 studies	27% ± 6%	Explore
T-helper 17 cell	4 studies	39% ± 19%	Explore
myoepithelial cell	4 studies	27% ± 6%	Explore
erythrocyte	4 studies	35% ± 13%	Explore
cholangiocyte	3 studies	38% ± 15%	Explore
glomerular endothelial cell	3 studies	21% ± 3%	Explore
neuron	3 studies	21% ± 7%	Explore
placental villous trophoblast	3 studies	40% ± 19%	Explore
immature B cell	3 studies	37% ± 9%	Explore
mesothelial cell	3 studies	33% ± 10%	Explore
germinal center B cell	3 studies	35% ± 9%	Explore
granulocyte	3 studies	33% ± 9%	Explore
neutrophil	3 studies	25% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 14%	Explore
melanocyte	3 studies	31% ± 11%	Explore
T-helper 1 cell	3 studies	55% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	54% ± 20%	Explore
double negative thymocyte	3 studies	61% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	71% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 3%	Explore
mural cell	3 studies	39% ± 27%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	47% ± 14%	Explore
lung	15 studies	27% ± 9%	Explore
brain	9 studies	25% ± 10%	Explore
bone marrow	4 studies	33% ± 14%	Explore
heart	4 studies	23% ± 6%	Explore
lymph node	4 studies	37% ± 17%	Explore
liver	4 studies	35% ± 15%	Explore
intestine	3 studies	20% ± 3%	Explore
kidney	3 studies	32% ± 9%	Explore
adipose	3 studies	28% ± 9%	Explore
breast	3 studies	20% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	12282.53	258 / 258	100%	99.10	230 / 230
esophagus	100%	4057.56	1445 / 1445	100%	42.67	183 / 183
skin	100%	4220.62	1809 / 1809	100%	59.97	472 / 472
thymus	100%	5709.69	652 / 653	100%	112.05	605 / 605
prostate	100%	4779.13	245 / 245	100%	31.74	501 / 502
uterus	100%	3751.04	170 / 170	100%	47.00	458 / 459
ovary	100%	3109.09	180 / 180	100%	49.42	429 / 430
lung	100%	9723.87	578 / 578	100%	57.44	1152 / 1155
brain	100%	4084.69	2633 / 2642	100%	56.17	705 / 705
stomach	100%	4586.82	359 / 359	100%	43.44	285 / 286
intestine	100%	4719.68	966 / 966	99%	42.56	523 / 527
breast	100%	6170.62	459 / 459	99%	42.35	1109 / 1118
bladder	100%	4143.33	21 / 21	99%	46.31	499 / 504
kidney	100%	3536.36	89 / 89	94%	42.44	845 / 901
pancreas	84%	1520.20	274 / 328	100%	61.35	178 / 178
liver	50%	764.59	112 / 226	72%	14.98	294 / 406
adipose	100%	6111.09	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	33.50	80 / 80
lymph node	0%	0	0 / 0	100%	106.71	29 / 29
peripheral blood	100%	19170.62	929 / 929	0%	0	0 / 0
spleen	100%	15013.19	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	39.59	45 / 45
ureter	0%	0	0 / 0	100%	13.78	1 / 1
heart	100%	3420.92	860 / 861	0%	0	0 / 0
blood vessel	100%	3845.46	1331 / 1335	0%	0	0 / 0
muscle	45%	656.72	358 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042098	Biological process	T cell proliferation
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0007165	Biological process	signal transduction
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301	Biological process	cell division
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0042127	Biological process	regulation of cell population proliferation
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0005813	Cellular component	centrosome
GO_0097133	Cellular component	cyclin D3-CDK6 complex
GO_0005654	Cellular component	nucleoplasm
GO_0000307	Cellular component	cyclin-dependent protein kinase holoenzyme complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0097130	Cellular component	cyclin D3-CDK4 complex
GO_0005634	Cellular component	nucleus
GO_0061575	Molecular function	cyclin-dependent protein serine/threonine kinase activator activity
GO_0019901	Molecular function	protein kinase binding
GO_0016538	Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity
GO_0005515	Molecular function	protein binding
GO_0004693	Molecular function	cyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]

Gene name	CCND3
Protein name	Cyclin D3, isoform CRA_c (cDNA FLJ38957 fis, clone NT2RI2000128, highly similar to G1/S-specific cyclin-D3) Cyclin D3 G1/S-specific cyclin-D3
Synonyms	hCG_16683
Description	FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase . Hypophosphorylates RB1 in early G(1) phase . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals . Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex . Shows transcriptional coactivator activity with ATF5 independently of CDK4 . .
Accessions	D6RI00 ENST00000514588.1 ENST00000505064.1 ENST00000616010.4 [P30281-4] ENST00000372987.8 ENST00000512426.5 ENST00000372988.8 [P30281-2] H0Y8M4 ENST00000372991.9 [P30281-1] ENST00000502771.1 P30281 ENST00000511642.5 [P30281-2] Q5T8J1 B3KTY3 ENST00000415497.6 [P30281-4] ENST00000510503.5 D6RIX2 ENST00000414200.6 [P30281-3] D6RDF8 ENST00000508143.5 D6RDL3 A0A1D5RMS0

CCND3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review