SMYD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007507Biological processheart development
GO_0043516Biological processregulation of DNA damage response, signal transduction by p53 class mediator
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0018027Biological processpeptidyl-lysine dimethylation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016278Molecular functionlysine N-methyltransferase activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0140999Molecular functionhistone H3K4 trimethyltransferase activity
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0046975Molecular functionhistone H3K36 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMYD2
Protein nameN-lysine methyltransferase SMYD2 (EC 2.1.1.354) (Histone methyltransferase SMYD2) (SET and MYND domain-containing protein 2)
SMYD2 protein
SET and MYND domain containing 2
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)
SynonymsKMT3C
DescriptionFUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. .

FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. .

AccessionsI6L9D1
Q05C86
Q9NRG4
ENST00000366957.10 [Q9NRG4-1]
B0R0U3
ENST00000416415.2