LDB1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LDB1 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0009948Biological processanterior/posterior axis specification
GO_0010669Biological processepithelial structure maintenance
GO_0021702Biological processcerebellar Purkinje cell differentiation
GO_0045647Biological processnegative regulation of erythrocyte differentiation
GO_0022607Biological processcellular component assembly
GO_0007155Biological processcell adhesion
GO_0045785Biological processpositive regulation of cell adhesion
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0030182Biological processneuron differentiation
GO_0043549Biological processregulation of kinase activity
GO_0030334Biological processregulation of cell migration
GO_0051893Biological processregulation of focal adhesion assembly
GO_0001942Biological processhair follicle development
GO_0016055Biological processWnt signaling pathway
GO_0007399Biological processnervous system development
GO_0046985Biological processpositive regulation of hemoglobin biosynthetic process
GO_0035019Biological processsomatic stem cell population maintenance
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001702Biological processgastrulation with mouth forming second
GO_0000972Biological processtranscription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0031252Cellular componentcell leading edge
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0030274Molecular functionLIM domain binding
GO_0003682Molecular functionchromatin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLDB1
Protein nameLIM domain binding 1
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
SynonymsCLIM2
hCG_25635
DescriptionFUNCTION: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. .

AccessionsENST00000425280.2
Q86U70
ENST00000361198.9 [Q86U70-2]
ENST00000673968.1 [Q86U70-1]
A0A6E1WJ75