KHDRBS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046833Biological processpositive regulation of RNA export from nucleus
GO_0007283Biological processspermatogenesis
GO_0045948Biological processpositive regulation of translational initiation
GO_0006397Biological processmRNA processing
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050852Biological processT cell receptor signaling pathway
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0046831Biological processregulation of RNA export from nucleus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031647Biological processregulation of protein stability
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0070618Cellular componentGrb2-Sos complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0008143Molecular functionpoly(A) binding
GO_0019904Molecular functionprotein domain specific binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0042169Molecular functionSH2 domain binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0008266Molecular functionpoly(U) RNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameKHDRBS1
Protein nameKH domain containing, RNA binding, signal transduction associated 1, isoform CRA_b (cDNA FLJ52899, highly similar to KH domain-containing, RNA-binding, signaltransduction-associated protein 1)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
SynonymshCG_41606
SAM68
DescriptionFUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to . RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 . Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). .; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. .

AccessionsENST00000327300.12 [Q07666-1]
Q07666
ENST00000492989.1 [Q07666-3]
B4E043