MAFK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAFK at tissue level.

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameMAFK
Protein nameV-maf musculoaponeurotic fibrosarcoma oncogene homolog K (Avian)
MAFK protein
Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit)
Synonyms
DescriptionFUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves . However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites . Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor . .

AccessionsO60675
A8WFP5
ENST00000343242.9
ENST00000403150.5
A2VCQ5
A2VCQ6
ENST00000406174.2