ZBTB17 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZBTB17 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070314Biological processG1 to G0 transition
GO_0045786Biological processnegative regulation of cell cycle
GO_0002682Biological processregulation of immune system process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001817Biological processregulation of cytokine production
GO_0007398Biological processectoderm development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001702Biological processgastrulation with mouth forming second
GO_0032993Cellular componentprotein-DNA complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0001223Molecular functiontranscription coactivator binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZBTB17
Protein nameZinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)
Zinc finger and BTB domain containing 17
SynonymsZNF60
MIZ1
ZNF151
DescriptionFUNCTION: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 . .

AccessionsENST00000375733.6 [Q13105-2]
ENST00000440560.5
Q13105
ENST00000444358.1
ENST00000375743.9 [Q13105-1]
ENST00000537142.5 [Q13105-3]
H0Y6X2
H7C1K8