STRAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030182Biological processneuron differentiation
GO_0030277Biological processmaintenance of gastrointestinal epithelium
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0000387Biological processspliceosomal snRNP assembly
GO_0034719Cellular componentSMN-Sm protein complex
GO_0005829Cellular componentcytosol
GO_0032797Cellular componentSMN complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_1990447Molecular functionU2 snRNP binding
GO_0005515Molecular functionprotein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSTRAP
Protein nameSerine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)
Serine/threonine kinase receptor associated protein
Serine-threonine kinase receptor-associated protein
SynonymsUNRIP
MAWD
DescriptionFUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. .

AccessionsF5H1G1
ENST00000538718.1
Q9Y3F4
ENST00000541731.1
ENST00000025399.10 [Q9Y3F4-2]
H0YH33
ENST00000419869.7 [Q9Y3F4-1]