PRMT6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRMT6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRMT6 at tissue level.

III. Associated gene sets

GO_0010821Biological processregulation of mitochondrion organization
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0032259Biological processmethylation
GO_0045652Biological processregulation of megakaryocyte differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0019919Biological processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO_0036211Biological processprotein modification process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0090398Biological processcellular senescence
GO_0006284Biological processbase-excision repair
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0070612Molecular functionhistone H2AR3 methyltransferase activity
GO_0070611Molecular functionhistone H3R2 methyltransferase activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0035241Molecular functionprotein-arginine omega-N monomethyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0008469Molecular functionhistone arginine N-methyltransferase activity
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0035242Molecular functionprotein-arginine omega-N asymmetric methyltransferase activity
GO_0044020Molecular functionhistone H4R3 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRMT6
Protein nameProtein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6)
Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) (Histone-arginine N-methyltransferase PRMT6)
SynonymsHRMT1L6
DescriptionFUNCTION: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA . Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates . Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a . H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) . Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 . Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity . Methylates HMGA1 . Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) . Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis . .

AccessionsENST00000370078.2 [Q96LA8-1]
A0A3B3ITK4
ENST00000650338.1
Q96LA8