RITA1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RITA1 at tissue level.

III. Associated gene sets

GO_0022008Biological processneurogenesis
GO_0051168Biological processnuclear export
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0007219Biological processNotch signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameRITA1
Protein nameRBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)
RBPJ interacting and tubulin associated 1
SynonymsRITA
PSEC0043
C12orf52
DescriptionFUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. .

AccessionsENST00000548278.2 [Q96K30-1]
ENST00000549621.5 [Q96K30-1]
Q96K30
ENST00000552495.1 [Q96K30-3]
A0A087X1G3
ENST00000615042.1