PROX1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	26 studies	57% ± 18%	Explore
oligodendrocyte	12 studies	27% ± 10%	Explore
retina horizontal cell	7 studies	68% ± 15%	Explore
hepatocyte	6 studies	58% ± 26%	Explore
retinal bipolar neuron	5 studies	52% ± 19%	Explore
cardiac muscle cell	5 studies	21% ± 3%	Explore
GABAergic neuron	5 studies	36% ± 8%	Explore
ON-bipolar cell	4 studies	45% ± 16%	Explore
brush cell	4 studies	33% ± 20%	Explore
interneuron	4 studies	49% ± 28%	Explore
ionocyte	3 studies	28% ± 5%	Explore
endothelial cell	3 studies	24% ± 10%	Explore
glycinergic amacrine cell	3 studies	41% ± 1%	Explore
rod bipolar cell	3 studies	72% ± 1%	Explore
Mueller cell	3 studies	24% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	24% ± 7%	Explore
eye	3 studies	19% ± 3%	Explore
liver	3 studies	40% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	9600.35	226 / 226	99%	46.33	400 / 406
brain	95%	1162.71	2517 / 2642	98%	12.48	694 / 705
adrenal gland	100%	2320.60	258 / 258	93%	22.16	214 / 230
intestine	93%	585.70	897 / 966	83%	12.91	437 / 527
pancreas	100%	2061.12	328 / 328	70%	5.92	125 / 178
thymus	100%	2374.79	651 / 653	48%	2.83	291 / 605
stomach	46%	179.16	164 / 359	71%	14.79	203 / 286
lung	72%	398.56	414 / 578	35%	3.37	401 / 1155
bladder	71%	359.14	15 / 21	33%	5.42	166 / 504
ovary	100%	1674.04	180 / 180	2%	0.12	9 / 430
spleen	100%	2105.22	241 / 241	0%	0	0 / 0
heart	93%	2052.36	799 / 861	0%	0	0 / 0
muscle	90%	700.03	723 / 803	0%	0	0 / 0
breast	69%	603.28	319 / 459	14%	0.74	158 / 1118
esophagus	43%	203.10	622 / 1445	39%	4.96	72 / 183
adipose	65%	500.23	788 / 1204	0%	0	0 / 0
uterus	48%	200.21	82 / 170	17%	1.32	78 / 459
skin	30%	131.67	541 / 1809	34%	2.17	162 / 472
prostate	37%	140.96	90 / 245	10%	0.39	51 / 502
kidney	33%	376.92	29 / 89	7%	0.43	64 / 901
tonsil	0%	0	0 / 0	22%	1.41	10 / 45
blood vessel	14%	95.84	186 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.53	9 / 80
lymph node	0%	0	0 / 0	7%	0.22	2 / 29
peripheral blood	0%	0.95	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0010468	Biological process	regulation of gene expression
GO_0060059	Biological process	embryonic retina morphogenesis in camera-type eye
GO_0045071	Biological process	negative regulation of viral genome replication
GO_0030324	Biological process	lung development
GO_0060298	Biological process	positive regulation of sarcomere organization
GO_0061114	Biological process	branching involved in pancreas morphogenesis
GO_0043049	Biological process	otic placode formation
GO_0060838	Biological process	lymphatic endothelial cell fate commitment
GO_0060214	Biological process	endocardium formation
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0060042	Biological process	retina morphogenesis in camera-type eye
GO_0060414	Biological process	aorta smooth muscle tissue morphogenesis
GO_0090425	Biological process	acinar cell differentiation
GO_0060837	Biological process	blood vessel endothelial cell differentiation
GO_0048845	Biological process	venous blood vessel morphogenesis
GO_1901978	Biological process	positive regulation of cell cycle checkpoint
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001822	Biological process	kidney development
GO_0055005	Biological process	ventricular cardiac myofibril assembly
GO_0055010	Biological process	ventricular cardiac muscle tissue morphogenesis
GO_0042752	Biological process	regulation of circadian rhythm
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0072574	Biological process	hepatocyte proliferation
GO_0021707	Biological process	cerebellar granule cell differentiation
GO_0070365	Biological process	hepatocyte differentiation
GO_0045787	Biological process	positive regulation of cell cycle
GO_0007405	Biological process	neuroblast proliferation
GO_0007406	Biological process	negative regulation of neuroblast proliferation
GO_0070858	Biological process	negative regulation of bile acid biosynthetic process
GO_0031016	Biological process	pancreas development
GO_0060836	Biological process	lymphatic endothelial cell differentiation
GO_0010631	Biological process	epithelial cell migration
GO_0021542	Biological process	dentate gyrus development
GO_0001946	Biological process	lymphangiogenesis
GO_0001889	Biological process	liver development
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0060421	Biological process	positive regulation of heart growth
GO_0002194	Biological process	hepatocyte cell migration
GO_0007420	Biological process	brain development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0055009	Biological process	atrial cardiac muscle tissue morphogenesis
GO_0030240	Biological process	skeletal muscle thin filament assembly
GO_0046619	Biological process	lens placode formation involved in camera-type eye formation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0021516	Biological process	dorsal spinal cord development
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0030910	Biological process	olfactory placode formation
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_2000979	Biological process	positive regulation of forebrain neuron differentiation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0007623	Biological process	circadian rhythm
GO_0031667	Biological process	response to nutrient levels
GO_0048664	Biological process	neuron fate determination
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0070309	Biological process	lens fiber cell morphogenesis
GO_0002088	Biological process	lens development in camera-type eye
GO_0021915	Biological process	neural tube development
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005829	Cellular component	cytosol
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0050693	Molecular function	LBD domain binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0050692	Molecular function	DNA binding domain binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0016922	Molecular function	nuclear receptor binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding

Gene name	PROX1
Protein name	Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) Prospero homeobox 1
Synonyms
Description	FUNCTION: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. .
Accessions	ENST00000366958.9 C9JU29 Q92786 ENST00000435016.2 ENST00000471129.1 U3KPY6 ENST00000607425.1

PROX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review