CUX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006891Biological processintra-Golgi vesicle-mediated transport
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005794Cellular componentGolgi apparatus
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameCUX1
Protein nameHomeobox protein cut-like
CUX1/RET fusion
Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]
Protein CASP
Cut like homeobox 1
Mutant CUX1
Synonymsfusion
CUTL1
RET
DescriptionFUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. .; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. .

FUNCTION: May be involved in intra-Golgi retrograde transport. .

AccessionsENST00000393824.7 [Q13948-9]
A0A2R8Y8D0
ENST00000292538.9 [Q13948-1]
ENST00000549414.6 [P39880-2]
T1SG88
ENST00000465461.7
Q13948
A0A7D4XDC1
ENST00000292535.12 [P39880-1]
ENST00000646649.1
A0A2R8Y852
A0A2R8YDI1
ENST00000622516.6 [Q13948-1]
ENST00000645010.1
P39880
ENST00000546411.7 [P39880-1]
ENST00000437600.9 [Q13948-2]
ENST00000550008.6 [P39880-5]
ENST00000360264.7 [P39880-3]
ENST00000547394.6 [Q13948-10]
ENST00000556210.1 [P39880-6]
ENST00000425244.6 [P39880-9]