NOP53 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_1902570Biological processprotein localization to nucleolus
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006974Biological processDNA damage response
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0000027Biological processribosomal large subunit assembly
GO_0001932Biological processregulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903006Biological processpositive regulation of protein K63-linked deubiquitination
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0039535Biological processregulation of RIG-I signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_1901837Biological processnegative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0050821Biological processprotein stabilization
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_1903715Biological processregulation of aerobic respiration
GO_1990173Biological processprotein localization to nucleoplasm
GO_0006364Biological processrRNA processing
GO_0051726Biological processregulation of cell cycle
GO_1901797Biological processnegative regulation of signal transduction by p53 class mediator
GO_0071456Biological processcellular response to hypoxia
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0033553Cellular componentrDNA heterochromatin
GO_0042802Molecular functionidentical protein binding
GO_0008097Molecular function5S rRNA binding
GO_0002039Molecular functionp53 binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOP53
Protein nameRibosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)
Ribosome biogenesis protein NOP53
SynonymsGLTSCR2
PICT1
GLT
DescriptionFUNCTION: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis . In ribosome biogenesis, may also play a role in rRNA transcription . Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions . DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation . It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation . Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway . May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 . May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation . Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex . May also regulate cellular aerobic respiration . In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI . .

AccessionsENST00000597985.5
M0QZ34
M0QZU5
ENST00000246802.10
Q96CS0
M0QYZ9
Q9NZM5
ENST00000598959.5
ENST00000595143.5
ENST00000594182.1
M0QX73