ZNF304 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF304 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF304 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0090309Biological processpositive regulation of DNA methylation-dependent heterochromatin formation
GO_0001525Biological processangiogenesis
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_2000811Biological processnegative regulation of anoikis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045766Biological processpositive regulation of angiogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF304
Protein nameZNF304 protein
Zinc finger protein 304 (KRAB-containing zinc finger protein)
Zinc finger protein 304
Synonyms
DescriptionFUNCTION: Acts as a transcriptional regulator and plays a role in gene silencing . Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites . Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways . Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression . Promotes angiogenesis . Promotes tumor growth . .

AccessionsENST00000282286.6
Q2T9G7
ENST00000391705.7
ENST00000598744.1
E7EQD3
M0QZ59
ENST00000443917.6
Q2T9G8
Q9HCX3