UBE2I | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	41% ± 14%	Explore
natural killer cell	36 studies	39% ± 12%	Explore
fibroblast	35 studies	32% ± 13%	Explore
CD8-positive, alpha-beta T cell	33 studies	39% ± 16%	Explore
endothelial cell	32 studies	31% ± 14%	Explore
T cell	30 studies	35% ± 12%	Explore
macrophage	29 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	29 studies	38% ± 16%	Explore
conventional dendritic cell	28 studies	38% ± 15%	Explore
pericyte	24 studies	33% ± 14%	Explore
regulatory T cell	24 studies	39% ± 12%	Explore
smooth muscle cell	23 studies	30% ± 13%	Explore
non-classical monocyte	22 studies	39% ± 17%	Explore
classical monocyte	22 studies	33% ± 15%	Explore
memory B cell	20 studies	46% ± 10%	Explore
mature NK T cell	19 studies	35% ± 11%	Explore
plasmacytoid dendritic cell	19 studies	38% ± 12%	Explore
basal cell	19 studies	34% ± 17%	Explore
naive B cell	19 studies	35% ± 8%	Explore
monocyte	18 studies	31% ± 9%	Explore
epithelial cell	18 studies	41% ± 19%	Explore
gamma-delta T cell	17 studies	41% ± 15%	Explore
dendritic cell	16 studies	40% ± 24%	Explore
mast cell	16 studies	32% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	32% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	39% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	41% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 9%	Explore
myofibroblast cell	14 studies	37% ± 13%	Explore
connective tissue cell	14 studies	42% ± 16%	Explore
plasma cell	13 studies	36% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	36% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	38% ± 12%	Explore
capillary endothelial cell	12 studies	29% ± 13%	Explore
mucosal invariant T cell	12 studies	35% ± 8%	Explore
myeloid cell	12 studies	38% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	36% ± 12%	Explore
endothelial cell of artery	11 studies	30% ± 14%	Explore
vein endothelial cell	11 studies	29% ± 15%	Explore
endothelial cell of vascular tree	11 studies	23% ± 5%	Explore
plasmablast	10 studies	45% ± 23%	Explore
abnormal cell	10 studies	41% ± 10%	Explore
secretory cell	9 studies	33% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	40% ± 16%	Explore
neuron	8 studies	41% ± 24%	Explore
T follicular helper cell	8 studies	37% ± 7%	Explore
type I pneumocyte	7 studies	28% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	44% ± 17%	Explore
goblet cell	7 studies	26% ± 13%	Explore
precursor B cell	7 studies	55% ± 11%	Explore
ciliated cell	7 studies	38% ± 16%	Explore
club cell	6 studies	29% ± 10%	Explore
leukocyte	6 studies	37% ± 11%	Explore
progenitor cell	6 studies	52% ± 6%	Explore
mesothelial cell	6 studies	57% ± 17%	Explore
transit amplifying cell	6 studies	25% ± 5%	Explore
innate lymphoid cell	6 studies	37% ± 6%	Explore
astrocyte	6 studies	24% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	43% ± 18%	Explore
alveolar macrophage	5 studies	21% ± 2%	Explore
hematopoietic precursor cell	5 studies	52% ± 23%	Explore
exhausted T cell	5 studies	50% ± 9%	Explore
mononuclear phagocyte	5 studies	36% ± 18%	Explore
enteroendocrine cell	5 studies	40% ± 15%	Explore
hematopoietic stem cell	5 studies	39% ± 9%	Explore
pro-B cell	5 studies	56% ± 10%	Explore
immature B cell	5 studies	49% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	47% ± 15%	Explore
granulocyte	5 studies	31% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	31% ± 12%	Explore
erythrocyte	5 studies	39% ± 22%	Explore
platelet	4 studies	19% ± 2%	Explore
pancreatic A cell	4 studies	36% ± 11%	Explore
intestinal crypt stem cell	4 studies	28% ± 4%	Explore
erythroblast	4 studies	51% ± 19%	Explore
lymphocyte	4 studies	40% ± 14%	Explore
type II pneumocyte	4 studies	34% ± 15%	Explore
microglial cell	4 studies	24% ± 4%	Explore
adventitial cell	4 studies	24% ± 9%	Explore
germinal center B cell	4 studies	43% ± 17%	Explore
intermediate monocyte	4 studies	46% ± 24%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 4%	Explore
glutamatergic neuron	4 studies	36% ± 13%	Explore
T-helper 17 cell	4 studies	41% ± 18%	Explore
oligodendrocyte	4 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 8%	Explore
double negative thymocyte	4 studies	49% ± 19%	Explore
ionocyte	3 studies	28% ± 10%	Explore
precursor cell	3 studies	60% ± 20%	Explore
glomerular endothelial cell	3 studies	24% ± 3%	Explore
enterocyte	3 studies	25% ± 7%	Explore
neural crest cell	3 studies	62% ± 15%	Explore
retinal bipolar neuron	3 studies	27% ± 8%	Explore
extravillous trophoblast	3 studies	36% ± 11%	Explore
placental villous trophoblast	3 studies	62% ± 11%	Explore
brush cell	3 studies	34% ± 14%	Explore
neuroendocrine cell	3 studies	36% ± 13%	Explore
Schwann cell	3 studies	35% ± 19%	Explore
amacrine cell	3 studies	33% ± 11%	Explore
retina horizontal cell	3 studies	30% ± 14%	Explore
serous secreting cell	3 studies	22% ± 1%	Explore
intraepithelial lymphocyte	3 studies	42% ± 18%	Explore
Mueller cell	3 studies	21% ± 8%	Explore
muscle cell	3 studies	28% ± 15%	Explore
CD4-positive helper T cell	3 studies	30% ± 9%	Explore
myoepithelial cell	3 studies	36% ± 12%	Explore
GABAergic neuron	3 studies	32% ± 8%	Explore
pancreatic ductal cell	3 studies	55% ± 7%	Explore
glial cell	3 studies	41% ± 27%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 15%	Explore
melanocyte	3 studies	25% ± 1%	Explore
keratinocyte	3 studies	26% ± 6%	Explore
interneuron	3 studies	28% ± 14%	Explore
T-helper 1 cell	3 studies	44% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	33% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	24% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	32% ± 15%	Explore
peripheral blood	17 studies	40% ± 13%	Explore
intestine	10 studies	30% ± 16%	Explore
brain	8 studies	26% ± 8%	Explore
kidney	6 studies	32% ± 11%	Explore
bone marrow	5 studies	27% ± 8%	Explore
liver	5 studies	37% ± 21%	Explore
lymph node	5 studies	42% ± 6%	Explore
pancreas	4 studies	36% ± 11%	Explore
eye	4 studies	27% ± 5%	Explore
uterus	4 studies	37% ± 16%	Explore
breast	4 studies	29% ± 3%	Explore
placenta	3 studies	42% ± 16%	Explore
adrenal gland	3 studies	29% ± 10%	Explore
prostate	3 studies	27% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	5016.24	258 / 258	100%	23.09	230 / 230
esophagus	100%	4797.24	1445 / 1445	100%	17.03	183 / 183
kidney	100%	3705.24	89 / 89	100%	17.70	901 / 901
ovary	100%	7137.98	180 / 180	100%	22.86	430 / 430
skin	100%	4933.06	1809 / 1809	100%	25.04	472 / 472
stomach	100%	3469.09	359 / 359	100%	22.08	286 / 286
thymus	100%	4409.61	653 / 653	100%	30.60	605 / 605
uterus	100%	6101.66	170 / 170	100%	24.73	459 / 459
lung	100%	4069.03	578 / 578	100%	18.75	1154 / 1155
brain	100%	4007.47	2638 / 2642	100%	21.52	705 / 705
intestine	100%	4984.85	966 / 966	100%	23.47	526 / 527
bladder	100%	5505.81	21 / 21	100%	22.79	503 / 504
prostate	100%	4619.03	245 / 245	100%	19.29	501 / 502
breast	100%	4857.14	459 / 459	99%	23.87	1111 / 1118
pancreas	99%	2037.08	325 / 328	99%	19.82	177 / 178
liver	100%	1569.84	226 / 226	96%	9.94	391 / 406
adipose	100%	4499.15	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5738.60	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	26.87	80 / 80
lymph node	0%	0	0 / 0	100%	31.72	29 / 29
spleen	100%	5393.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.56	45 / 45
ureter	0%	0	0 / 0	100%	21.68	1 / 1
muscle	100%	2741.45	801 / 803	0%	0	0 / 0
heart	100%	3023.48	858 / 861	0%	0	0 / 0
peripheral blood	97%	3429.37	903 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016925	Biological process	protein sumoylation
GO_1903755	Biological process	positive regulation of SUMO transferase activity
GO_0007059	Biological process	chromosome segregation
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0051301	Biological process	cell division
GO_0051168	Biological process	nuclear export
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030335	Biological process	positive regulation of cell migration
GO_0036211	Biological process	protein modification process
GO_0007084	Biological process	mitotic nuclear membrane reassembly
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0106068	Cellular component	SUMO ligase complex
GO_0000795	Cellular component	synaptonemal complex
GO_0005643	Cellular component	nuclear pore
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0005829	Cellular component	cytosol
GO_0016605	Cellular component	PML body
GO_1990234	Cellular component	transferase complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008134	Molecular function	transcription factor binding
GO_0019899	Molecular function	enzyme binding
GO_0019789	Molecular function	SUMO transferase activity
GO_0044388	Molecular function	small protein activating enzyme binding
GO_0001221	Molecular function	transcription coregulator binding
GO_0071535	Molecular function	RING-like zinc finger domain binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0061656	Molecular function	SUMO conjugating enzyme activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	UBE2I
Protein name	SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) SUMO-conjugating enzyme UBC9 SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Synonyms	UBCE9 UBC9 hCG_42687
Description	FUNCTION: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity . .
Accessions	ENST00000567383.6 ENST00000566775.2 H3BPC4 ENST00000397515.6 H3BRD1 ENST00000567074.6 ENST00000566587.5 ENST00000403747.6 Q7KZS0 ENST00000397514.8 H3BQQ9 B0QYN7 ENST00000567383 ENST00000355803.8 P63279 ENST00000402301.5 ENST00000677314.1 ENST00000567074 ENST00000325437.9 ENST00000562470.3 ENST00000406620.6

UBE2I report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review