NCOA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_1904179Biological processpositive regulation of adipose tissue development
GO_0045475Biological processlocomotor rhythm
GO_1904017Biological processcellular response to Thyroglobulin triiodothyronine
GO_0019216Biological processregulation of lipid metabolic process
GO_0010906Biological processregulation of glucose metabolic process
GO_0032870Biological processcellular response to hormone stimulus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0032570Biological processresponse to progesterone
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0017162Molecular functionaryl hydrocarbon receptor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003682Molecular functionchromatin binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0001162Molecular functionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCOA2
Protein nameNCOA2 protein
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)
Nuclear receptor coactivator 2
SynonymsBHLHE75
SRC2
TIF2
DescriptionFUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors . Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) . Required with NCOA1 to control energy balance between white and brown adipose tissues . Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression . Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 . Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). .

AccessionsH0YBB6
E7EWM1
ENST00000519724.1
ENST00000518287.6
ENST00000518363.2
E5RFN9
A0A0B6XJZ8
ENST00000452400.7
Q569J4
ENST00000520416.1
A0A1D5RMT0
Q15596