Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 22 studies | 42% ± 14% | |
astrocyte | 20 studies | 46% ± 19% | |
oligodendrocyte | 16 studies | 37% ± 13% | |
oligodendrocyte precursor cell | 15 studies | 49% ± 18% | |
microglial cell | 15 studies | 50% ± 15% | |
glutamatergic neuron | 13 studies | 49% ± 22% | |
macrophage | 12 studies | 46% ± 18% | |
GABAergic neuron | 11 studies | 58% ± 23% | |
fibroblast | 11 studies | 43% ± 13% | |
smooth muscle cell | 10 studies | 33% ± 13% | |
pericyte | 9 studies | 45% ± 14% | |
adipocyte | 9 studies | 38% ± 12% | |
epithelial cell | 8 studies | 39% ± 19% | |
T cell | 8 studies | 36% ± 12% | |
interneuron | 7 studies | 60% ± 22% | |
mast cell | 7 studies | 28% ± 11% | |
ciliated cell | 7 studies | 36% ± 16% | |
non-classical monocyte | 6 studies | 22% ± 9% | |
neuron | 6 studies | 51% ± 25% | |
retina horizontal cell | 6 studies | 52% ± 24% | |
retinal cone cell | 6 studies | 54% ± 24% | |
B cell | 6 studies | 35% ± 12% | |
dendritic cell | 6 studies | 37% ± 7% | |
myeloid cell | 6 studies | 33% ± 12% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 9% | |
basal cell | 6 studies | 41% ± 22% | |
cardiac muscle cell | 5 studies | 49% ± 15% | |
monocyte | 5 studies | 49% ± 9% | |
club cell | 5 studies | 43% ± 19% | |
type I pneumocyte | 5 studies | 41% ± 8% | |
type II pneumocyte | 5 studies | 48% ± 9% | |
hepatocyte | 4 studies | 66% ± 26% | |
classical monocyte | 4 studies | 20% ± 4% | |
granule cell | 4 studies | 42% ± 9% | |
plasma cell | 4 studies | 37% ± 11% | |
retinal ganglion cell | 4 studies | 50% ± 24% | |
CD4-positive, alpha-beta T cell | 4 studies | 36% ± 9% | |
CD8-positive, alpha-beta T cell | 4 studies | 33% ± 10% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 29% ± 12% | |
mesothelial cell | 4 studies | 33% ± 13% | |
lymphocyte | 4 studies | 43% ± 21% | |
Mueller cell | 4 studies | 38% ± 19% | |
amacrine cell | 4 studies | 40% ± 11% | |
retinal rod cell | 4 studies | 59% ± 20% | |
natural killer cell | 4 studies | 41% ± 8% | |
leukocyte | 4 studies | 59% ± 8% | |
cholangiocyte | 3 studies | 45% ± 18% | |
hepatic stellate cell | 3 studies | 47% ± 20% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 47% ± 5% | |
GABAergic interneuron | 3 studies | 63% ± 5% | |
progenitor cell | 3 studies | 40% ± 2% | |
vein endothelial cell | 3 studies | 30% ± 14% | |
GABAergic amacrine cell | 3 studies | 37% ± 11% | |
glycinergic amacrine cell | 3 studies | 35% ± 7% | |
endothelial cell of vascular tree | 3 studies | 36% ± 15% | |
retinal pigment epithelial cell | 3 studies | 42% ± 14% | |
neural progenitor cell | 3 studies | 50% ± 11% | |
ependymal cell | 3 studies | 54% ± 18% | |
alveolar macrophage | 3 studies | 47% ± 10% | |
capillary endothelial cell | 3 studies | 33% ± 7% | |
respiratory goblet cell | 3 studies | 50% ± 19% | |
goblet cell | 3 studies | 43% ± 33% | |
transit amplifying cell | 3 studies | 40% ± 34% | |
mural cell | 3 studies | 48% ± 4% | |
mucus secreting cell | 3 studies | 42% ± 5% | |
regulatory T cell | 3 studies | 35% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3504.67 | 1445 / 1445 | 100% | 27.29 | 183 / 183 |
prostate | 100% | 3289.24 | 245 / 245 | 99% | 28.43 | 499 / 502 |
ovary | 100% | 3838.46 | 180 / 180 | 99% | 20.10 | 427 / 430 |
breast | 100% | 3686.48 | 459 / 459 | 99% | 34.72 | 1109 / 1118 |
lung | 100% | 3089.45 | 577 / 578 | 99% | 21.28 | 1147 / 1155 |
brain | 100% | 2396.76 | 2629 / 2642 | 99% | 20.22 | 700 / 705 |
stomach | 100% | 2035.30 | 359 / 359 | 99% | 22.13 | 282 / 286 |
intestine | 100% | 3061.94 | 966 / 966 | 98% | 17.04 | 516 / 527 |
liver | 100% | 3202.46 | 226 / 226 | 98% | 20.35 | 397 / 406 |
thymus | 100% | 3167.49 | 653 / 653 | 98% | 18.93 | 590 / 605 |
kidney | 100% | 2406.55 | 89 / 89 | 97% | 19.57 | 877 / 901 |
bladder | 100% | 4029.90 | 21 / 21 | 97% | 15.93 | 489 / 504 |
pancreas | 99% | 1333.37 | 324 / 328 | 97% | 15.61 | 173 / 178 |
adrenal gland | 100% | 2880.69 | 258 / 258 | 95% | 14.30 | 219 / 230 |
uterus | 100% | 3093.54 | 170 / 170 | 95% | 15.73 | 434 / 459 |
skin | 100% | 3355.08 | 1809 / 1809 | 94% | 16.19 | 442 / 472 |
adipose | 100% | 3277.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3374.27 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3015.70 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.59 | 1 / 1 |
muscle | 100% | 1799.26 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 2277.21 | 837 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 18.72 | 43 / 45 |
peripheral blood | 95% | 2969.78 | 883 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 12.13 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 83% | 12.23 | 66 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035357 | Biological process | peroxisome proliferator activated receptor signaling pathway |
GO_1904179 | Biological process | positive regulation of adipose tissue development |
GO_0045475 | Biological process | locomotor rhythm |
GO_1904017 | Biological process | cellular response to Thyroglobulin triiodothyronine |
GO_0019216 | Biological process | regulation of lipid metabolic process |
GO_0010906 | Biological process | regulation of glucose metabolic process |
GO_0032870 | Biological process | cellular response to hormone stimulus |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0032922 | Biological process | circadian regulation of gene expression |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0042789 | Biological process | mRNA transcription by RNA polymerase II |
GO_1900076 | Biological process | regulation of cellular response to insulin stimulus |
GO_0032570 | Biological process | response to progesterone |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
GO_0016604 | Cellular component | nuclear body |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0016922 | Molecular function | nuclear receptor binding |
GO_0017162 | Molecular function | aryl hydrocarbon receptor binding |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0001162 | Molecular function | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
GO_0046983 | Molecular function | protein dimerization activity |
GO_0030374 | Molecular function | nuclear receptor coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NCOA2 |
Protein name | NCOA2 protein Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Nuclear receptor coactivator 2 |
Synonyms | BHLHE75 SRC2 TIF2 |
Description | FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors . Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) . Required with NCOA1 to control energy balance between white and brown adipose tissues . Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression . Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 . Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). . |
Accessions | H0YBB6 E7EWM1 ENST00000519724.1 ENST00000518287.6 ENST00000518363.2 E5RFN9 A0A0B6XJZ8 ENST00000452400.7 Q569J4 ENST00000520416.1 A0A1D5RMT0 Q15596 |