MAGEL2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAGEL2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	85%	594.72	2238 / 2642	92%	5.35	646 / 705
pancreas	88%	93.04	289 / 328	58%	1.77	103 / 178
ovary	99%	377.47	178 / 180	38%	1.68	165 / 430
thymus	92%	130.13	603 / 653	34%	1.00	203 / 605
breast	73%	65.08	334 / 459	38%	0.73	430 / 1118
uterus	94%	298.05	160 / 170	16%	2.80	73 / 459
prostate	68%	53.00	166 / 245	33%	0.81	166 / 502
eye	0%	0	0 / 0	78%	2.56	62 / 80
adrenal gland	26%	24.87	67 / 258	48%	8.19	110 / 230
skin	24%	21.32	430 / 1809	38%	3.07	180 / 472
spleen	61%	59.50	148 / 241	0%	0	0 / 0
adipose	57%	45.28	685 / 1204	0%	0	0 / 0
intestine	50%	34.54	479 / 966	7%	0.20	38 / 527
bladder	33%	25.33	7 / 21	11%	0.49	57 / 504
stomach	29%	19.16	103 / 359	11%	0.28	31 / 286
lung	18%	11.24	105 / 578	14%	0.39	160 / 1155
esophagus	17%	9.83	246 / 1445	15%	0.26	27 / 183
kidney	20%	11.31	18 / 89	5%	0.26	48 / 901
blood vessel	10%	6.26	139 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	7%	0.08	3 / 45
heart	6%	3.76	50 / 861	0%	0	0 / 0
liver	2%	1.49	4 / 226	1%	0.01	3 / 406
muscle	1%	0.36	6 / 803	0%	0	0 / 0
peripheral blood	0%	0.04	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_0034314	Biological process	Arp2/3 complex-mediated actin nucleation
GO_0051127	Biological process	positive regulation of actin nucleation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048511	Biological process	rhythmic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0070534	Biological process	protein K63-linked ubiquitination
GO_0042752	Biological process	regulation of circadian rhythm
GO_0030904	Cellular component	retromer complex
GO_0005768	Cellular component	endosome
GO_0005829	Cellular component	cytosol
GO_0005769	Cellular component	early endosome
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

Gene name	MAGEL2
Protein name	MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) MAGEL2 protein
Synonyms	NDNL1
Description	FUNCTION: Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly . Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity). .
Accessions	ENST00000673192.1 Q6P3U4 Q9UJ55 ENST00000650528.1 Q05BN9 Q2M1Q7 ENST00000672700.1

MAGEL2 report