TAF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTAF3
Protein nameTAF3 protein
Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)
TATA-box binding protein associated factor 3
Synonyms
DescriptionFUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C . TAF3 forms the TFIID-A module together with TAF5 and TBP . Required in complex with TBPL2 for the differentiation of myoblasts into myocytes . The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process . .

AccessionsQ0VGM1
ENST00000344293.6
ENST00000686593.1
ENST00000687522.1
A0A8I5QJF0
A0A8I5KR98
Q5VWG9