NSMCE3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0016925Biological processprotein sumoylation
GO_0072711Biological processcellular response to hydroxyurea
GO_0006281Biological processDNA repair
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032204Biological processregulation of telomere maintenance
GO_0071478Biological processcellular response to radiation
GO_0034644Biological processcellular response to UV
GO_0140588Biological processchromatin looping
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNSMCE3
Protein nameNon-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)
SynonymsNDNL2
MAGEG1
HCA4
DescriptionFUNCTION: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination . The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex . May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). .

AccessionsENST00000332303.6
Q96MG7
ENST00000631973.1