Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 5 studies | 21% ± 3% | |
| CD4-positive, alpha-beta T cell | 4 studies | 25% ± 8% | |
| plasmablast | 3 studies | 31% ± 18% | |
| erythroblast | 3 studies | 30% ± 13% | |
| pro-B cell | 3 studies | 26% ± 2% |
Insufficient scRNA-seq data for expression of AURKB at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 90% | 684.85 | 1630 / 1809 | 95% | 38.90 | 450 / 472 |
| intestine | 52% | 284.91 | 500 / 966 | 96% | 45.14 | 505 / 527 |
| lung | 58% | 135.80 | 336 / 578 | 84% | 33.05 | 973 / 1155 |
| stomach | 45% | 181.18 | 163 / 359 | 95% | 40.03 | 271 / 286 |
| esophagus | 43% | 340.37 | 615 / 1445 | 97% | 40.63 | 177 / 183 |
| bladder | 19% | 25.05 | 4 / 21 | 95% | 50.06 | 480 / 504 |
| uterus | 7% | 17.33 | 12 / 170 | 98% | 71.53 | 452 / 459 |
| ovary | 6% | 19.03 | 11 / 180 | 95% | 33.22 | 408 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 114.70 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 90.70 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 17.09 | 1 / 1 |
| spleen | 99% | 652.63 | 238 / 241 | 0% | 0 | 0 / 0 |
| breast | 21% | 30.44 | 95 / 459 | 75% | 21.37 | 838 / 1118 |
| peripheral blood | 90% | 1400.92 | 837 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 5% | 7.06 | 16 / 328 | 62% | 13.75 | 110 / 178 |
| liver | 15% | 44.58 | 35 / 226 | 46% | 10.72 | 187 / 406 |
| adrenal gland | 38% | 55.31 | 98 / 258 | 12% | 3.12 | 28 / 230 |
| eye | 0% | 0 | 0 / 0 | 44% | 5.21 | 35 / 80 |
| brain | 1% | 2.06 | 29 / 2642 | 39% | 11.44 | 275 / 705 |
| kidney | 18% | 45.97 | 16 / 89 | 10% | 2.15 | 94 / 901 |
| prostate | 16% | 23.34 | 39 / 245 | 11% | 1.63 | 56 / 502 |
| thymus | 10% | 17.87 | 63 / 653 | 16% | 16.76 | 99 / 605 |
| adipose | 23% | 38.10 | 275 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 12% | 15.74 | 160 / 1335 | 0% | 0 | 0 / 0 |
| heart | 6% | 10.05 | 50 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.41 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032466 | Biological process | negative regulation of cytokinesis |
| GO_0008608 | Biological process | attachment of spindle microtubules to kinetochore |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_1904355 | Biological process | positive regulation of telomere capping |
| GO_0034644 | Biological process | cellular response to UV |
| GO_0007052 | Biological process | mitotic spindle organization |
| GO_0009838 | Biological process | abscission |
| GO_0002903 | Biological process | negative regulation of B cell apoptotic process |
| GO_0062033 | Biological process | positive regulation of mitotic sister chromatid segregation |
| GO_0044878 | Biological process | mitotic cytokinesis checkpoint signaling |
| GO_1901970 | Biological process | positive regulation of mitotic sister chromatid separation |
| GO_0160049 | Biological process | negative regulation of cGAS/STING signaling pathway |
| GO_0000281 | Biological process | mitotic cytokinesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0043687 | Biological process | post-translational protein modification |
| GO_0034501 | Biological process | protein localization to kinetochore |
| GO_0090307 | Biological process | mitotic spindle assembly |
| GO_0045824 | Biological process | negative regulation of innate immune response |
| GO_0051256 | Biological process | mitotic spindle midzone assembly |
| GO_0051983 | Biological process | regulation of chromosome segregation |
| GO_1901796 | Biological process | regulation of signal transduction by p53 class mediator |
| GO_0051973 | Biological process | positive regulation of telomerase activity |
| GO_0090267 | Biological process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO_1902425 | Biological process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO_0044839 | Biological process | cell cycle G2/M phase transition |
| GO_1903490 | Biological process | positive regulation of mitotic cytokinesis |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
| GO_0036089 | Biological process | cleavage furrow formation |
| GO_0032467 | Biological process | positive regulation of cytokinesis |
| GO_1905116 | Biological process | positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore |
| GO_0032465 | Biological process | regulation of cytokinesis |
| GO_0007051 | Biological process | spindle organization |
| GO_0097431 | Cellular component | mitotic spindle pole |
| GO_0005876 | Cellular component | spindle microtubule |
| GO_0030496 | Cellular component | midbody |
| GO_0010369 | Cellular component | chromocenter |
| GO_0031616 | Cellular component | spindle pole centrosome |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0032133 | Cellular component | chromosome passenger complex |
| GO_1990023 | Cellular component | mitotic spindle midzone |
| GO_0051233 | Cellular component | spindle midzone |
| GO_0005829 | Cellular component | cytosol |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0000779 | Cellular component | condensed chromosome, centromeric region |
| GO_0005819 | Cellular component | spindle |
| GO_0005634 | Cellular component | nucleus |
| GO_0004712 | Molecular function | protein serine/threonine/tyrosine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0019900 | Molecular function | kinase binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AURKB |
| Protein name | Aurora kinase (EC 2.7.11.1) Aurora kinase B Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) |
| Synonyms | STK5 STK1 AIK2 ARK2 AIM1 STK12 AIRK2 |
| Description | FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis . The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly . Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis . Required for central/midzone spindle assembly and cleavage furrow formation . Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis . AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP . Phosphorylation of INCENP leads to increased AURKB activity . Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 . A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres . Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) . AURKB is also required for kinetochore localization of BUB1 and SGO1 . Phosphorylation of p53/TP53 negatively regulates its transcriptional activity . Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity . Phosphorylates KRT5 during anaphase and telophase (By similarity). . |
| Accessions | ENST00000582368.5 ENST00000581511.5 ENST00000584972.5 ENST00000585124.6 [Q96GD4-1] J3KRF8 ENST00000316199.10 [Q96GD4-5] ENST00000577833.5 ENST00000578549.5 [Q96GD4-2] ENST00000534871.5 [Q96GD4-4] ENST00000580998.5 J3KTD6 ENST00000583915.1 J3QR41 Q96GD4 J3QLN8 J3KRJ2 J3KT86 |
