ZEB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_0030900Biological processforebrain development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0090103Biological processcochlea morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0014823Biological processresponse to activity
GO_0045602Biological processnegative regulation of endothelial cell differentiation
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0031667Biological processresponse to nutrient levels
GO_0010464Biological processregulation of mesenchymal cell proliferation
GO_0048752Biological processsemicircular canal morphogenesis
GO_0030154Biological processcell differentiation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0048856Biological processanatomical structure development
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0033081Biological processregulation of T cell differentiation in thymus
GO_0051216Biological processcartilage development
GO_0051150Biological processregulation of smooth muscle cell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043616Biological processkeratinocyte proliferation
GO_0007389Biological processpattern specification process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZEB1
Protein nameZEB1 protein
Alternative protein ZEB1
Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)
Zinc finger E-box binding homeobox 1
Zinc finger E-box-binding homeobox 1
SynonymsTCF8
AREB6
DescriptionFUNCTION: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). .

AccessionsF6TDF5
ENST00000446923.7 [P37275-5]
ENST00000561212.5
ENST00000558440.5
Q32Q63
P37275
ENST00000542815.7 [P37275-3]
ENST00000424869.6 [P37275-2]
ENST00000424869
L0R5E9
ENST00000560721.6 [P37275-4]
L8EAF3
H0YND9
ENST00000320985.14 [P37275-1]
H0YMD3
A0JLS9
ENST00000437844.6
F6U0D0