Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 5 studies | 36% ± 14% | |
| GABAergic neuron | 3 studies | 36% ± 9% | |
| astrocyte | 3 studies | 21% ± 2% | |
| interneuron | 3 studies | 31% ± 14% | |
| oligodendrocyte precursor cell | 3 studies | 18% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 572.34 | 1445 / 1445 | 100% | 10.27 | 183 / 183 |
| breast | 100% | 673.90 | 459 / 459 | 100% | 10.12 | 1114 / 1118 |
| uterus | 100% | 731.48 | 170 / 170 | 100% | 12.87 | 457 / 459 |
| lung | 99% | 431.74 | 575 / 578 | 100% | 9.87 | 1155 / 1155 |
| liver | 100% | 459.64 | 226 / 226 | 99% | 7.32 | 403 / 406 |
| bladder | 100% | 651.38 | 21 / 21 | 99% | 9.20 | 500 / 504 |
| brain | 99% | 369.24 | 2619 / 2642 | 100% | 10.06 | 705 / 705 |
| intestine | 100% | 639.84 | 966 / 966 | 99% | 8.30 | 521 / 527 |
| pancreas | 99% | 368.87 | 326 / 328 | 99% | 7.01 | 177 / 178 |
| stomach | 100% | 428.12 | 359 / 359 | 99% | 8.70 | 282 / 286 |
| thymus | 100% | 430.75 | 652 / 653 | 99% | 6.35 | 596 / 605 |
| prostate | 100% | 520.46 | 245 / 245 | 98% | 6.99 | 493 / 502 |
| adrenal gland | 100% | 456.15 | 258 / 258 | 98% | 5.98 | 225 / 230 |
| ovary | 100% | 540.03 | 180 / 180 | 97% | 6.60 | 419 / 430 |
| skin | 100% | 568.33 | 1806 / 1809 | 92% | 7.49 | 433 / 472 |
| kidney | 100% | 346.79 | 89 / 89 | 91% | 6.07 | 819 / 901 |
| adipose | 100% | 692.88 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 615.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 437.62 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 11.58 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.66 | 1 / 1 |
| muscle | 100% | 640.31 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 331.24 | 831 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 8.67 | 27 / 29 |
| eye | 0% | 0 | 0 / 0 | 70% | 3.30 | 56 / 80 |
| peripheral blood | 42% | 231.51 | 390 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0035102 | Cellular component | PRC1 complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PCGF6 |
| Protein name | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) Polycomb group ring finger 6 |
| Synonyms | MBLR RNF134 |
| Description | FUNCTION: Transcriptional repressor . May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase . Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . . |
| Accessions | A0A3B3ISZ4 ENST00000337211.8 [Q9BYE7-3] ENST00000647574.1 Q9BYE7 ENST00000369847.4 [Q9BYE7-1] |
