MAGEA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAGEA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAGEA1 at tissue level.

III. Associated gene sets

GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMAGEA1
Protein nameMAGE-1 protein
Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)
Melanoma antigen family A 1
SynonymsMAGE1A
MAGE1
DescriptionFUNCTION: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. .

AccessionsP43355
A8IF97
Q8WX99
ENST00000356661.7