Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 30 studies | 42% ± 22% | |
fibroblast | 25 studies | 37% ± 17% | |
smooth muscle cell | 18 studies | 37% ± 20% | |
mast cell | 18 studies | 45% ± 23% | |
astrocyte | 14 studies | 61% ± 21% | |
mesothelial cell | 14 studies | 58% ± 16% | |
oligodendrocyte | 13 studies | 36% ± 13% | |
oligodendrocyte precursor cell | 12 studies | 45% ± 15% | |
endothelial cell of lymphatic vessel | 11 studies | 29% ± 11% | |
ciliated cell | 11 studies | 27% ± 9% | |
pericyte | 11 studies | 25% ± 9% | |
glutamatergic neuron | 9 studies | 42% ± 23% | |
endothelial cell of artery | 9 studies | 38% ± 20% | |
adipocyte | 9 studies | 37% ± 18% | |
basal cell | 8 studies | 28% ± 10% | |
connective tissue cell | 8 studies | 45% ± 22% | |
vein endothelial cell | 8 studies | 34% ± 18% | |
retinal rod cell | 8 studies | 39% ± 19% | |
endothelial cell of vascular tree | 8 studies | 25% ± 11% | |
capillary endothelial cell | 7 studies | 38% ± 19% | |
myofibroblast cell | 7 studies | 47% ± 22% | |
retinal cone cell | 7 studies | 65% ± 18% | |
neuron | 6 studies | 39% ± 20% | |
amacrine cell | 6 studies | 28% ± 13% | |
epithelial cell | 6 studies | 34% ± 19% | |
retinal ganglion cell | 6 studies | 28% ± 11% | |
cardiac muscle cell | 6 studies | 62% ± 21% | |
secretory cell | 4 studies | 20% ± 4% | |
pancreatic A cell | 4 studies | 38% ± 12% | |
type B pancreatic cell | 4 studies | 54% ± 24% | |
glomerular endothelial cell | 4 studies | 75% ± 6% | |
progenitor cell | 4 studies | 60% ± 27% | |
GABAergic amacrine cell | 4 studies | 55% ± 15% | |
type II pneumocyte | 4 studies | 21% ± 2% | |
pancreatic D cell | 3 studies | 57% ± 21% | |
endothelial cell of sinusoid | 3 studies | 35% ± 15% | |
GABAergic neuron | 3 studies | 22% ± 5% | |
interstitial cell of Cajal | 3 studies | 82% ± 10% | |
granule cell | 3 studies | 26% ± 6% | |
endocardial cell | 3 studies | 47% ± 14% | |
glycinergic amacrine cell | 3 studies | 28% ± 11% | |
hepatocyte | 3 studies | 28% ± 9% | |
retinal pigment epithelial cell | 3 studies | 44% ± 31% | |
mucus secreting cell | 3 studies | 42% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 5823.83 | 245 / 245 | 92% | 10.04 | 463 / 502 |
brain | 94% | 2727.72 | 2474 / 2642 | 98% | 14.56 | 692 / 705 |
adrenal gland | 100% | 3931.12 | 258 / 258 | 92% | 9.98 | 211 / 230 |
pancreas | 92% | 843.81 | 301 / 328 | 96% | 10.57 | 170 / 178 |
esophagus | 98% | 2776.09 | 1420 / 1445 | 84% | 4.56 | 154 / 183 |
uterus | 100% | 6856.69 | 170 / 170 | 82% | 7.65 | 375 / 459 |
lung | 99% | 1416.36 | 571 / 578 | 81% | 4.41 | 937 / 1155 |
skin | 92% | 1162.00 | 1672 / 1809 | 86% | 6.69 | 405 / 472 |
ovary | 100% | 2824.30 | 180 / 180 | 69% | 4.79 | 295 / 430 |
bladder | 100% | 4839.62 | 21 / 21 | 66% | 3.93 | 333 / 504 |
kidney | 99% | 2055.62 | 88 / 89 | 61% | 3.82 | 551 / 901 |
breast | 100% | 1560.98 | 457 / 459 | 50% | 2.18 | 560 / 1118 |
stomach | 88% | 1950.80 | 315 / 359 | 55% | 3.67 | 158 / 286 |
liver | 70% | 634.25 | 158 / 226 | 69% | 5.56 | 282 / 406 |
thymus | 98% | 1220.17 | 639 / 653 | 39% | 4.33 | 234 / 605 |
intestine | 83% | 4011.46 | 805 / 966 | 37% | 2.28 | 197 / 527 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.96 | 1 / 1 |
blood vessel | 99% | 1800.84 | 1317 / 1335 | 0% | 0 | 0 / 0 |
spleen | 98% | 1153.28 | 237 / 241 | 0% | 0 | 0 / 0 |
adipose | 97% | 1515.81 | 1172 / 1204 | 0% | 0 | 0 / 0 |
heart | 95% | 1561.12 | 821 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 3.80 | 34 / 45 |
eye | 0% | 0 | 0 / 0 | 41% | 1.94 | 33 / 80 |
lymph node | 0% | 0 | 0 / 0 | 38% | 1.91 | 11 / 29 |
peripheral blood | 2% | 22.88 | 21 / 929 | 0% | 0 | 0 / 0 |
muscle | 0% | 0.61 | 1 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045638 | Biological process | negative regulation of myeloid cell differentiation |
GO_0110024 | Biological process | positive regulation of cardiac muscle myoblast proliferation |
GO_0031016 | Biological process | pancreas development |
GO_0009887 | Biological process | animal organ morphogenesis |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0008542 | Biological process | visual learning |
GO_0001654 | Biological process | eye development |
GO_0045931 | Biological process | positive regulation of mitotic cell cycle |
GO_0009880 | Biological process | embryonic pattern specification |
GO_0007420 | Biological process | brain development |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0009612 | Biological process | response to mechanical stimulus |
GO_0070848 | Biological process | response to growth factor |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0008134 | Molecular function | transcription factor binding |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MEIS2 |
Protein name | Meis1, myeloid ecotropic viral integration site 1 homolog 2 (Mouse), isoform CRA_f (cDNA FLJ31374 fis, clone NB9N42000430, highly similar to HOMEOBOX PROTEIN MEIS2) Homeobox protein Meis2 (Meis1-related protein 1) Meis homeobox 2 |
Synonyms | MRG1 hCG_39301 |
Description | FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. . |
Accessions | ENST00000699903.1 [O14770-7] H0YM65 ENST00000606653.5 ENST00000559561.5 [O14770-3] ENST00000397624.7 A0A8V8TPM6 ENST00000699955.1 O14770 ENST00000559085.5 [O14770-8] ENST00000557796.6 [O14770-7] ENST00000607277.5 ENST00000699904.1 U3KQ95 ENST00000560697.5 A0A8V8TPB7 ENST00000340545.9 [O14770-7] ENST00000397620.6 ENST00000338564.9 [O14770-4] A0A9H3ZWV7 H0YKE5 H0YKN2 U3KQI2 B3KP81 ENST00000314177.12 [O14770-5] A0A8V8TQU6 ENST00000699956.1 ENST00000560617.5 ENST00000560570.5 ENST00000561208.6 [O14770-1] ENST00000424352.6 [O14770-2] |