MEIS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0110024Biological processpositive regulation of cardiac muscle myoblast proliferation
GO_0031016Biological processpancreas development
GO_0009887Biological processanimal organ morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0008542Biological processvisual learning
GO_0001654Biological processeye development
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0009880Biological processembryonic pattern specification
GO_0007420Biological processbrain development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0009612Biological processresponse to mechanical stimulus
GO_0070848Biological processresponse to growth factor
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMEIS2
Protein nameMeis1, myeloid ecotropic viral integration site 1 homolog 2 (Mouse), isoform CRA_f (cDNA FLJ31374 fis, clone NB9N42000430, highly similar to HOMEOBOX PROTEIN MEIS2)
Homeobox protein Meis2 (Meis1-related protein 1)
Meis homeobox 2
SynonymsMRG1
hCG_39301
DescriptionFUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. .

AccessionsENST00000699903.1 [O14770-7]
H0YM65
ENST00000606653.5
ENST00000559561.5 [O14770-3]
ENST00000397624.7
A0A8V8TPM6
ENST00000699955.1
O14770
ENST00000559085.5 [O14770-8]
ENST00000557796.6 [O14770-7]
ENST00000607277.5
ENST00000699904.1
U3KQ95
ENST00000560697.5
A0A8V8TPB7
ENST00000340545.9 [O14770-7]
ENST00000397620.6
ENST00000338564.9 [O14770-4]
A0A9H3ZWV7
H0YKE5
H0YKN2
U3KQI2
B3KP81
ENST00000314177.12 [O14770-5]
A0A8V8TQU6
ENST00000699956.1
ENST00000560617.5
ENST00000560570.5
ENST00000561208.6 [O14770-1]
ENST00000424352.6 [O14770-2]