SIM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SIM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIM2 at tissue level.

III. Associated gene sets

GO_0009880Biological processembryonic pattern specification
GO_0030324Biological processlung development
GO_0007399Biological processnervous system development
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding

IV. Literature review

[source]
Gene nameSIM2
Protein nameSingle-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
SIM bHLH transcription factor 2
SynonymsBHLHE15
DescriptionFUNCTION: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

AccessionsENST00000431229.1
V9GY04
H7BZX8
ENST00000483178.2
ENST00000290399.11 [Q14190-1]
Q14190