PURB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017148Biological processnegative regulation of translation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045637Biological processregulation of myeloid cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0032422Molecular functionpurine-rich negative regulatory element binding
GO_0046332Molecular functionSMAD binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003729Molecular functionmRNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene namePURB
Protein nameTranscriptional regulator protein Pur-beta (Purine-rich element-binding protein B)
Synonyms
DescriptionFUNCTION: Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene . Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). .

AccessionsENST00000395699.5
Q96QR8