NFIC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	41 studies	42% ± 13%	Explore
endothelial cell	35 studies	31% ± 12%	Explore
pericyte	27 studies	27% ± 10%	Explore
smooth muscle cell	26 studies	34% ± 13%	Explore
macrophage	24 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	18 studies	30% ± 10%	Explore
basal cell	17 studies	33% ± 13%	Explore
astrocyte	17 studies	32% ± 14%	Explore
ciliated cell	16 studies	32% ± 12%	Explore
connective tissue cell	14 studies	35% ± 12%	Explore
myofibroblast cell	14 studies	45% ± 10%	Explore
epithelial cell	13 studies	35% ± 21%	Explore
microglial cell	13 studies	33% ± 13%	Explore
type I pneumocyte	12 studies	30% ± 9%	Explore
capillary endothelial cell	12 studies	25% ± 4%	Explore
oligodendrocyte	12 studies	29% ± 11%	Explore
vein endothelial cell	12 studies	25% ± 8%	Explore
type II pneumocyte	10 studies	33% ± 11%	Explore
endothelial cell of artery	10 studies	24% ± 6%	Explore
myeloid cell	10 studies	29% ± 10%	Explore
adipocyte	10 studies	44% ± 9%	Explore
endothelial cell of vascular tree	10 studies	29% ± 10%	Explore
club cell	9 studies	28% ± 7%	Explore
glutamatergic neuron	9 studies	35% ± 21%	Explore
GABAergic neuron	8 studies	34% ± 19%	Explore
secretory cell	7 studies	36% ± 10%	Explore
abnormal cell	7 studies	34% ± 18%	Explore
mesothelial cell	7 studies	33% ± 8%	Explore
monocyte	7 studies	21% ± 5%	Explore
dendritic cell	7 studies	22% ± 12%	Explore
ionocyte	6 studies	30% ± 7%	Explore
classical monocyte	6 studies	25% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	23% ± 9%	Explore
respiratory goblet cell	5 studies	30% ± 7%	Explore
adventitial cell	5 studies	45% ± 6%	Explore
mucus secreting cell	5 studies	28% ± 9%	Explore
cardiac muscle cell	5 studies	34% ± 8%	Explore
hepatocyte	5 studies	62% ± 19%	Explore
duct epithelial cell	4 studies	32% ± 9%	Explore
pancreatic A cell	4 studies	37% ± 16%	Explore
type B pancreatic cell	4 studies	47% ± 27%	Explore
conventional dendritic cell	4 studies	29% ± 9%	Explore
hematopoietic precursor cell	4 studies	24% ± 6%	Explore
neuron	4 studies	35% ± 16%	Explore
amacrine cell	4 studies	35% ± 13%	Explore
retinal bipolar neuron	4 studies	39% ± 6%	Explore
retinal ganglion cell	4 studies	52% ± 21%	Explore
retinal pigment epithelial cell	4 studies	42% ± 19%	Explore
retinal rod cell	4 studies	17% ± 3%	Explore
lymphocyte	4 studies	25% ± 8%	Explore
Mueller cell	4 studies	27% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 10%	Explore
muscle cell	4 studies	46% ± 14%	Explore
oligodendrocyte precursor cell	4 studies	31% ± 10%	Explore
interneuron	4 studies	43% ± 20%	Explore
pancreatic D cell	3 studies	41% ± 18%	Explore
non-classical monocyte	3 studies	26% ± 11%	Explore
glomerular endothelial cell	3 studies	24% ± 5%	Explore
retinal cone cell	3 studies	22% ± 6%	Explore
serous secreting cell	3 studies	24% ± 5%	Explore
glial cell	3 studies	23% ± 3%	Explore
mononuclear phagocyte	3 studies	26% ± 7%	Explore
OFF-bipolar cell	3 studies	29% ± 5%	Explore
ON-bipolar cell	3 studies	35% ± 8%	Explore
rod bipolar cell	3 studies	42% ± 10%	Explore
cholangiocyte	3 studies	63% ± 9%	Explore
pancreatic ductal cell	3 studies	51% ± 19%	Explore
ependymal cell	3 studies	37% ± 21%	Explore
enteroendocrine cell	3 studies	24% ± 8%	Explore
intestinal crypt stem cell	3 studies	23% ± 5%	Explore
alveolar macrophage	3 studies	29% ± 7%	Explore
chondrocyte	3 studies	38% ± 8%	Explore
melanocyte	3 studies	25% ± 7%	Explore
goblet cell	3 studies	39% ± 25%	Explore
transit amplifying cell	3 studies	48% ± 24%	Explore
keratinocyte	3 studies	27% ± 2%	Explore
myoepithelial cell	3 studies	35% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 11%	Explore
renal alpha-intercalated cell	3 studies	22% ± 6%	Explore
renal principal cell	3 studies	24% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	25% ± 8%	Explore
brain	13 studies	32% ± 15%	Explore
eye	9 studies	28% ± 11%	Explore
intestine	5 studies	23% ± 7%	Explore
kidney	5 studies	20% ± 4%	Explore
heart	5 studies	27% ± 7%	Explore
breast	5 studies	24% ± 4%	Explore
pancreas	4 studies	43% ± 20%	Explore
adipose	4 studies	32% ± 11%	Explore
peripheral blood	3 studies	20% ± 1%	Explore
uterus	3 studies	41% ± 4%	Explore
liver	3 studies	34% ± 7%	Explore
skin	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	15900.72	258 / 258	100%	61.92	230 / 230
esophagus	100%	17697.91	1445 / 1445	100%	90.08	183 / 183
prostate	100%	14191.46	245 / 245	100%	77.58	502 / 502
thymus	100%	12108.68	652 / 653	100%	71.01	605 / 605
ovary	100%	16484.96	180 / 180	100%	76.54	428 / 430
breast	100%	12768.01	459 / 459	99%	79.72	1107 / 1118
skin	100%	12654.80	1808 / 1809	99%	49.56	467 / 472
kidney	100%	6682.29	89 / 89	98%	50.23	887 / 901
pancreas	100%	11629.94	328 / 328	98%	43.19	175 / 178
liver	100%	9526.15	226 / 226	98%	48.87	397 / 406
brain	98%	6951.02	2588 / 2642	99%	65.08	701 / 705
uterus	100%	17517.76	170 / 170	97%	46.89	444 / 459
lung	100%	11130.22	578 / 578	97%	46.15	1116 / 1155
stomach	100%	11262.06	359 / 359	92%	49.47	262 / 286
intestine	100%	13260.55	962 / 966	88%	32.17	462 / 527
bladder	100%	14554.19	21 / 21	87%	25.79	436 / 504
adipose	100%	12220.74	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16717.43	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	51.75	80 / 80
muscle	100%	37009.75	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	25.57	1 / 1
heart	99%	11667.85	849 / 861	0%	0	0 / 0
spleen	98%	5046.55	237 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	48.77	42 / 45
lymph node	0%	0	0 / 0	76%	12.44	22 / 29
peripheral blood	25%	823.00	230 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006260	Biological process	DNA replication
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001650	Cellular component	fibrillar center
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]

Gene name	NFIC
Protein name	Nuclear factor 1 Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Synonyms	NFI
Description	FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. . FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. .
Accessions	ENST00000586919.5 [P08651-4] ENST00000590282.5 [P08651-6] A0A286YEX4 ENST00000395111.7 [P08651-3] Q6FI30 ENST00000641145.1 ENST00000443272.3 [P08651-1] P08651 ENST00000589123.5 [P08651-2] ENST00000341919.7 [P08651-5]

NFIC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review