PTCH1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	10 studies	31% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	30% ± 11%	Explore
fibroblast	8 studies	30% ± 9%	Explore
Mueller cell	6 studies	23% ± 7%	Explore
myofibroblast cell	5 studies	31% ± 7%	Explore
GABAergic neuron	4 studies	22% ± 5%	Explore
oligodendrocyte	4 studies	20% ± 3%	Explore
smooth muscle cell	3 studies	24% ± 7%	Explore
endothelial cell	3 studies	31% ± 15%	Explore
interneuron	3 studies	18% ± 3%	Explore
epithelial cell	3 studies	20% ± 5%	Explore
glutamatergic neuron	3 studies	31% ± 7%	Explore
connective tissue cell	3 studies	28% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	26% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	3383.32	2627 / 2642	97%	17.43	683 / 705
stomach	100%	2720.79	359 / 359	94%	9.76	269 / 286
prostate	100%	2363.50	244 / 245	94%	7.03	473 / 502
intestine	98%	2548.53	951 / 966	94%	8.57	494 / 527
pancreas	99%	1402.29	324 / 328	86%	4.85	153 / 178
thymus	100%	2101.07	650 / 653	76%	3.60	457 / 605
esophagus	94%	1365.03	1364 / 1445	80%	6.34	147 / 183
ovary	98%	1838.21	177 / 180	72%	3.58	309 / 430
skin	99%	1506.30	1799 / 1809	68%	3.32	322 / 472
lung	95%	1657.45	549 / 578	67%	4.22	775 / 1155
kidney	94%	1045.30	84 / 89	61%	2.73	547 / 901
bladder	100%	4188.57	21 / 21	55%	3.55	275 / 504
adrenal gland	93%	1272.13	240 / 258	57%	2.72	131 / 230
uterus	96%	2307.49	164 / 170	44%	2.45	201 / 459
breast	98%	1207.70	450 / 459	34%	1.26	379 / 1118
spleen	97%	885.37	234 / 241	0%	0	0 / 0
adipose	97%	1274.06	1166 / 1204	0%	0	0 / 0
blood vessel	96%	1339.82	1283 / 1335	0%	0	0 / 0
heart	73%	543.97	629 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	70%	2.61	56 / 80
lymph node	0%	0	0 / 0	59%	2.70	17 / 29
liver	38%	227.63	85 / 226	20%	0.78	82 / 406
muscle	54%	375.19	432 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	47%	2.29	21 / 45
peripheral blood	25%	422.16	234 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008589	Biological process	regulation of smoothened signaling pathway
GO_0032355	Biological process	response to estradiol
GO_0045606	Biological process	positive regulation of epidermal cell differentiation
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0007224	Biological process	smoothened signaling pathway
GO_0010157	Biological process	response to chlorate
GO_0048568	Biological process	embryonic organ development
GO_0072659	Biological process	protein localization to plasma membrane
GO_0001701	Biological process	in utero embryonic development
GO_0001709	Biological process	cell fate determination
GO_0072205	Biological process	metanephric collecting duct development
GO_0009887	Biological process	animal organ morphogenesis
GO_0061053	Biological process	somite development
GO_0021532	Biological process	neural tube patterning
GO_0051782	Biological process	negative regulation of cell division
GO_0032880	Biological process	regulation of protein localization
GO_0016485	Biological process	protein processing
GO_0030850	Biological process	prostate gland development
GO_0045879	Biological process	negative regulation of smoothened signaling pathway
GO_0009957	Biological process	epidermal cell fate specification
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060603	Biological process	mammary gland duct morphogenesis
GO_0021904	Biological process	dorsal/ventral neural tube patterning
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0040015	Biological process	negative regulation of multicellular organism growth
GO_0010839	Biological process	negative regulation of keratinocyte proliferation
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0035137	Biological process	hindlimb morphogenesis
GO_0061005	Biological process	cell differentiation involved in kidney development
GO_2000647	Biological process	negative regulation of stem cell proliferation
GO_0071679	Biological process	commissural neuron axon guidance
GO_0097421	Biological process	liver regeneration
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0071397	Biological process	cellular response to cholesterol
GO_0030326	Biological process	embryonic limb morphogenesis
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0021997	Biological process	neural plate axis specification
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0060644	Biological process	mammary gland epithelial cell differentiation
GO_0001843	Biological process	neural tube closure
GO_0072203	Biological process	cell proliferation involved in metanephros development
GO_0035108	Biological process	limb morphogenesis
GO_0007420	Biological process	brain development
GO_0043616	Biological process	keratinocyte proliferation
GO_0032526	Biological process	response to retinoic acid
GO_0009612	Biological process	response to mechanical stimulus
GO_0048745	Biological process	smooth muscle tissue development
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0021522	Biological process	spinal cord motor neuron differentiation
GO_0003007	Biological process	heart morphogenesis
GO_0007286	Biological process	spermatid development
GO_0042593	Biological process	glucose homeostasis
GO_0060037	Biological process	pharyngeal system development
GO_0072089	Biological process	stem cell proliferation
GO_0030496	Cellular component	midbody
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0060170	Cellular component	ciliary membrane
GO_0044294	Cellular component	dendritic growth cone
GO_0044295	Cellular component	axonal growth cone
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0045177	Cellular component	apical part of cell
GO_0005901	Cellular component	caveola
GO_0008201	Molecular function	heparin binding
GO_0015485	Molecular function	cholesterol binding
GO_0008158	Molecular function	hedgehog receptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0005119	Molecular function	smoothened binding
GO_0097108	Molecular function	hedgehog family protein binding
GO_0005113	Molecular function	patched binding
GO_0005515	Molecular function	protein binding
GO_0030332	Molecular function	cyclin binding

IV. Literature review

[source]

Gene name	PTCH1
Protein name	Patched-like protein 1 delta15 splice variant Patched homolog 1 splice variant 1C variant Protein patched homolog 1 (PTC) (PTC1) Patched homolog (Drosophila), isoform CRA_b (Patched-like protein 1 delta10 splice variant) Patched 1
Synonyms	hCG_32204 PTCH
Description	FUNCTION: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. .
Accessions	ENST00000551845.5 ENST00000547672.5 H0YHK0 ENST00000430669.6 [Q13635-3] ENST00000468211.6 ENST00000331920.11 [Q13635-1] ENST00000690194.1 F8VXL8 A0A1W5YLI7 A0A0C4DGJ5 H0Y3B8 A0A6M5WRE7 ENST00000551630.1 ENST00000546820.5 ENST00000429896.6 [Q13635-4] A0A1W5YLI4 ENST00000550914.6 ENST00000375271.4 ENST00000553011.5 A0A6M5WRG3 ENST00000692981.1 [Q13635-4] A3KBF6 H3BLX7 Q13635 F8VQS6 ENST00000375290.6 A0A8I5KPP5 ENST00000548420.1 ENST00000711046.1 [Q13635-3] F8VPA3 ENST00000437951.6 [Q13635-2] ENST00000551623.1 A0A0C4DGI4

PTCH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review