TBX6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TBX6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBX6 at tissue level.

III. Associated gene sets

GO_0007498Biological processmesoderm development
GO_0001708Biological processcell fate specification
GO_0014043Biological processnegative regulation of neuron maturation
GO_0001947Biological processheart looping
GO_0032525Biological processsomite rostral/caudal axis specification
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001570Biological processvasculogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0010977Biological processnegative regulation of neuron projection development
GO_0009653Biological processanatomical structure morphogenesis
GO_0007501Biological processmesodermal cell fate specification
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBX6
Protein nameT-box transcription factor TBX6 (T-box protein 6)
T-box transcription factor TBX6
Synonyms
DescriptionFUNCTION: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). .

AccessionsENST00000395224.7 [O95947-1]
ENST00000279386.6 [O95947-1]
ENST00000567664.5 [O95947-2]
X5DP27
ENST00000553607.1 [O95947-2]
X5D304
O95947