ZNF431 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameZNF431
Protein nameZinc finger protein 431
SynonymshCG_1783490
KIAA1969
DescriptionFUNCTION: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). .

AccessionsENST00000594425.5
ENST00000311048.11
M0R1H8
ENST00000600692.5
M0QZN7
Q8TF32
ENST00000599296.5
ENST00000598331.1
M0QZG4
M0QXY3