Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 5 studies | 52% ± 13% | |
| Mueller cell | 5 studies | 24% ± 6% | |
| OFF-bipolar cell | 3 studies | 39% ± 4% | |
| ON-bipolar cell | 3 studies | 39% ± 5% | |
| rod bipolar cell | 3 studies | 72% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 3 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 91% | 10.98 | 2399 / 2642 | 1% | 0.01 | 5 / 705 |
| breast | 72% | 6.48 | 329 / 459 | 2% | 0.05 | 23 / 1118 |
| adipose | 72% | 8.16 | 861 / 1204 | 0% | 0 | 0 / 0 |
| skin | 44% | 2.62 | 798 / 1809 | 0% | 0.00 | 1 / 472 |
| blood vessel | 41% | 1.52 | 546 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 37% | 1.44 | 362 / 966 | 0% | 0.00 | 1 / 527 |
| lung | 34% | 1.74 | 197 / 578 | 1% | 0.20 | 9 / 1155 |
| bladder | 33% | 1.62 | 7 / 21 | 0% | 0.05 | 2 / 504 |
| thymus | 29% | 0.94 | 189 / 653 | 0% | 0.01 | 2 / 605 |
| esophagus | 28% | 0.89 | 411 / 1445 | 1% | 0.01 | 1 / 183 |
| eye | 0% | 0 | 0 / 0 | 25% | 5.20 | 20 / 80 |
| spleen | 24% | 0.70 | 59 / 241 | 0% | 0 | 0 / 0 |
| ovary | 22% | 0.66 | 40 / 180 | 1% | 0.09 | 6 / 430 |
| prostate | 22% | 0.63 | 55 / 245 | 1% | 0.02 | 3 / 502 |
| uterus | 21% | 0.62 | 36 / 170 | 2% | 0.06 | 8 / 459 |
| stomach | 21% | 0.65 | 75 / 359 | 0% | 0 | 0 / 286 |
| muscle | 17% | 0.52 | 139 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 17% | 1.23 | 159 / 929 | 0% | 0 | 0 / 0 |
| liver | 15% | 0.36 | 33 / 226 | 1% | 0.04 | 3 / 406 |
| kidney | 15% | 0.61 | 13 / 89 | 0% | 0.00 | 1 / 901 |
| heart | 14% | 0.38 | 123 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 13% | 0.31 | 33 / 258 | 0% | 0 | 0 / 230 |
| pancreas | 11% | 0.26 | 35 / 328 | 1% | 0.02 | 1 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.06 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Gene name | VSX2 |
| Protein name | Visual system homeobox 2 Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) |
| Synonyms | CHX10 HOX10 |
| Description | FUNCTION: Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters . Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). May play a role in specification of V2a interneurons during spinal cord development (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 . Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements . Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling . . |
| Accessions | ENST00000261980.3 A0A0C5GDS6 A0A0C5GPM8 A0A0H3W5U6 A0A0Y0SDY8 A0A0C5G2R3 A0A0C5G2R6 A0A127AXL4 A0A0H3W5J1 A0A127AYT6 P58304 A0A0C5GCB1 A0A0Y0SIA8 A0A0C5G9Q3 A0A0C5G9Q0 A0A0C5GPM7 |
