FEZF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FEZF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FEZF2 at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0021853Biological processcerebral cortex GABAergic interneuron migration
GO_0021542Biological processdentate gyrus development
GO_0043697Biological processcell dedifferentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0021902Biological processcommitment of neuronal cell to specific neuron type in forebrain
GO_0007413Biological processaxonal fasciculation
GO_1902667Biological processregulation of axon guidance
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0048664Biological processneuron fate determination
GO_0021797Biological processforebrain anterior/posterior pattern specification
GO_0050767Biological processregulation of neurogenesis
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0016358Biological processdendrite development
GO_0007626Biological processlocomotory behavior
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameFEZF2
Protein nameFez family zinc finger protein 2 (Forebrain embryonic zinc finger-like protein 2) (Zinc finger protein 312) (Zinc finger protein Fez-like)
SynonymsFKSG36
FEZL
ZNF312
DescriptionFUNCTION: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity). .

AccessionsENST00000486811.5 [Q8TBJ5-1]
ENST00000283268.8 [Q8TBJ5-1]
ENST00000475839.1 [Q8TBJ5-1]
Q8TBJ5