PAX6 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	9 studies	28% ± 11%	Explore
amacrine cell	8 studies	69% ± 15%	Explore
retinal ganglion cell	7 studies	66% ± 25%	Explore
retina horizontal cell	6 studies	60% ± 16%	Explore
Mueller cell	6 studies	53% ± 16%	Explore
pancreatic A cell	4 studies	57% ± 22%	Explore
type B pancreatic cell	4 studies	56% ± 21%	Explore
GABAergic amacrine cell	4 studies	71% ± 6%	Explore
glycinergic amacrine cell	4 studies	61% ± 7%	Explore
pancreatic D cell	3 studies	38% ± 20%	Explore
granule cell	3 studies	37% ± 10%	Explore
basal cell	3 studies	38% ± 30%	Explore
enteroendocrine cell	3 studies	26% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	8 studies	31% ± 8%	Explore
pancreas	3 studies	52% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	2249.10	2615 / 2642	92%	3.75	646 / 705
pancreas	96%	383.92	314 / 328	32%	1.31	57 / 178
uterus	0%	0	0 / 170	21%	0.46	97 / 459
ovary	1%	1.58	2 / 180	15%	0.49	65 / 430
esophagus	0%	0.50	6 / 1445	15%	0.36	28 / 183
tonsil	0%	0	0 / 0	16%	0.40	7 / 45
lung	0%	0	0 / 578	13%	0.28	146 / 1155
stomach	4%	13.37	15 / 359	5%	0.10	15 / 286
bladder	0%	0	0 / 21	9%	0.22	43 / 504
adrenal gland	5%	12.86	13 / 258	3%	0.22	7 / 230
intestine	3%	4.05	32 / 966	4%	0.09	19 / 527
skin	3%	4.70	51 / 1809	3%	0.05	12 / 472
breast	0%	0	0 / 459	5%	0.16	58 / 1118
eye	0%	0	0 / 0	5%	0.19	4 / 80
kidney	1%	3.21	1 / 89	2%	0.05	16 / 901
liver	0%	0	0 / 226	2%	0.04	10 / 406
thymus	0%	0.18	1 / 653	1%	0.01	4 / 605
peripheral blood	0%	0.56	3 / 929	0%	0	0 / 0
blood vessel	0%	0.36	4 / 1335	0%	0	0 / 0
adipose	0%	0.28	3 / 1204	0%	0	0 / 0
muscle	0%	0.33	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0032808	Biological process	lacrimal gland development
GO_0022027	Biological process	interkinetic nuclear migration
GO_0021798	Biological process	forebrain dorsal/ventral pattern formation
GO_0023019	Biological process	signal transduction involved in regulation of gene expression
GO_0042462	Biological process	eye photoreceptor cell development
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0098598	Biological process	learned vocalization behavior or vocal learning
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0007417	Biological process	central nervous system development
GO_0021549	Biological process	cerebellum development
GO_0048856	Biological process	anatomical structure development
GO_0021593	Biological process	rhombomere morphogenesis
GO_0030858	Biological process	positive regulation of epithelial cell differentiation
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0007224	Biological process	smoothened signaling pathway
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0048596	Biological process	embryonic camera-type eye morphogenesis
GO_0001709	Biological process	cell fate determination
GO_0001755	Biological process	neural crest cell migration
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0010628	Biological process	positive regulation of gene expression
GO_0000132	Biological process	establishment of mitotic spindle orientation
GO_0033365	Biological process	protein localization to organelle
GO_0021902	Biological process	commitment of neuronal cell to specific neuron type in forebrain
GO_0048708	Biological process	astrocyte differentiation
GO_0001654	Biological process	eye development
GO_0001568	Biological process	blood vessel development
GO_0010975	Biological process	regulation of neuron projection development
GO_0061072	Biological process	iris morphogenesis
GO_0007399	Biological process	nervous system development
GO_0007405	Biological process	neuroblast proliferation
GO_0007406	Biological process	negative regulation of neuroblast proliferation
GO_0071380	Biological process	cellular response to prostaglandin E stimulus
GO_0030216	Biological process	keratinocyte differentiation
GO_0007601	Biological process	visual perception
GO_1904937	Biological process	sensory neuron migration
GO_1904798	Biological process	positive regulation of core promoter binding
GO_0009786	Biological process	regulation of asymmetric cell division
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0009887	Biological process	animal organ morphogenesis
GO_2001224	Biological process	positive regulation of neuron migration
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0045471	Biological process	response to ethanol
GO_0009950	Biological process	dorsal/ventral axis specification
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0061034	Biological process	olfactory bulb mitral cell layer development
GO_1901142	Biological process	insulin metabolic process
GO_0021778	Biological process	oligodendrocyte cell fate specification
GO_0009611	Biological process	response to wounding
GO_0007435	Biological process	salivary gland morphogenesis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0048505	Biological process	regulation of timing of cell differentiation
GO_0021905	Biological process	forebrain-midbrain boundary formation
GO_0003309	Biological process	type B pancreatic cell differentiation
GO_0061303	Biological process	cornea development in camera-type eye
GO_0003322	Biological process	pancreatic A cell development
GO_0120008	Biological process	positive regulation of glutamatergic neuron differentiation
GO_0048663	Biological process	neuron fate commitment
GO_0021517	Biological process	ventral spinal cord development
GO_0060041	Biological process	retina development in camera-type eye
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0021796	Biological process	cerebral cortex regionalization
GO_0002088	Biological process	lens development in camera-type eye
GO_0021986	Biological process	habenula development
GO_0042660	Biological process	positive regulation of cell fate specification
GO_0021983	Biological process	pituitary gland development
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0042593	Biological process	glucose homeostasis
GO_0007411	Biological process	axon guidance
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005829	Cellular component	cytosol
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0070410	Molecular function	co-SMAD binding
GO_0035035	Molecular function	histone acetyltransferase binding
GO_0000979	Molecular function	RNA polymerase II core promoter sequence-specific DNA binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0001221	Molecular function	transcription coregulator binding
GO_0003680	Molecular function	minor groove of adenine-thymine-rich DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0070412	Molecular function	R-SMAD binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0019901	Molecular function	protein kinase binding
GO_0071837	Molecular function	HMG box domain binding

IV. Literature review

[source]

Gene name	PAX6
Protein name	Paired box protein Pax-6 PAX6 Paired box 6 (Paired box gene 6 (Aniridia, keratitis), isoform CRA_b) PAX6 protein Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin) Truncated PAX6 protein Paired box 6 Alternative protein PAX6 Mutant PAX6 protein
Synonyms	hCG_26499 AN2
Description	FUNCTION: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity). .
Accessions	ENST00000640368.2 [P26367-2] Q6VMP0 ENST00000638878.1 B1B1I8 P26367 Q6RYC5 A0A1W2PS91 ENST00000379115.9 A0A1W2PRG3 ENST00000640684.1 E9PKM0 Q2XU31 Q8IVH0 A0A1W2PQM7 A0A1W2PPM5 A0A1W2PQG7 ENST00000639950.1 ENST00000638802.1 A0A1W2PQW3 ENST00000640460.1 B1B1J0 A0A1W2PRU4 ENST00000639034.2 A0A1W2PQL7 A0A1W2PQ31 F1T0F8 ENST00000638629.1 ENST00000638346.1 ENST00000379123.10 B1B1I9 ENST00000524853.6 ENST00000640335.1 ENST00000639916.1 [P26367-1] Q7Z5Y4 A0A1W2PNS7 ENST00000640766.1 Q7Z6F0 D1KF47 ENST00000241001.13 [P26367-1] A0A1W2PPJ2 ENST00000643871.1 [P26367-1] Q56H36 ENST00000640872.1 ENST00000638685.1 ENST00000639079.1 ENST00000379107.7 [P26367-2] ENST00000379132.8 [P26367-1] ENST00000639394.1 ENST00000638965.1 A0A1W2PRH6 A0A1W2PP89 L8E7A6 A0A1W2PSA8 A0A1W2PRA4 A0A1W2PPG3 ENST00000639386.2 A0A1W2PQG3 A0A1W2PQJ8 Q66SS1 ENST00000640610.1 [P26367-1] ENST00000639006.1 A0A1W2PQA8 A0A1X7SBT0 ENST00000606377.7 [P26367-2] A0A1W2PSB5 ENST00000379109.7 [P26367-1] ENST00000640431.1 ENST00000639061.1 ENST00000640963.1 A0A1W2PPH0 ENST00000638250.1 ENST00000423822.7 ENST00000379129.7 [P26367-2] ENST00000638963.1 ENST00000639548.1 ENST00000638762.1 ENST00000640242.1 ENST00000379111.7 ENST00000639109.1 A0A1W2PR58 ENST00000419022.6 [P26367-2] ENST00000639920.1 Q2XU32 A0A1W2PRA8 ENST00000638755.1 A0A1W2PRS6 ENST00000640975.1 [P26367-2] ENST00000481563.6 ENST00000438681.6 E5LBD7 A0A1W2PP27 ENST00000640287.1 [P26367-1] ENST00000639409.1 [P26367-2] ENST00000640125.1 Q6VMN9 ENST00000455099.6 ENST00000638696.1 ENST00000639943.1 ENST00000638853.1 A0A1W2PPN2 ENST00000640613.1 ENST00000638914.3 [P26367-2] A0A1W2PRW7

PAX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review