NEDD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0031623Biological processreceptor internalization
GO_0042391Biological processregulation of membrane potential
GO_0006622Biological processprotein targeting to lysosome
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0034644Biological processcellular response to UV
GO_0045087Biological processinnate immune response
GO_0046755Biological processviral budding
GO_0031175Biological processneuron projection development
GO_0007041Biological processlysosomal transport
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0030948Biological processnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO_1901016Biological processregulation of potassium ion transmembrane transporter activity
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007528Biological processneuromuscular junction development
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0042921Biological processnuclear receptor-mediated glucocorticoid signaling pathway
GO_0050807Biological processregulation of synapse organization
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0010766Biological processnegative regulation of sodium ion transport
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0046824Biological processpositive regulation of nucleocytoplasmic transport
GO_0016241Biological processregulation of macroautophagy
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_0044111Biological processformation of structure involved in a symbiotic process
GO_0051592Biological processresponse to calcium ion
GO_0032801Biological processreceptor catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0016327Cellular componentapicolateral plasma membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019899Molecular functionenzyme binding
GO_0043130Molecular functionubiquitin binding
GO_0019904Molecular functionprotein domain specific binding
GO_0070064Molecular functionproline-rich region binding
GO_0031698Molecular functionbeta-2 adrenergic receptor binding
GO_0019871Molecular functionsodium channel inhibitor activity
GO_0050816Molecular functionphosphothreonine residue binding
GO_0050815Molecular functionphosphoserine residue binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEDD4
Protein nameNEDD4 E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
SynonymsRPF1
PIG53
NEDD4-1
KIAA0093
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins . Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes . Promotes ubiquitination of RAPGEF2 . According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 . Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 . Ubiquitinates DAZAP2, leading to its proteasomal degradation . Ubiquitinates POLR2A . Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes . .; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. .

AccessionsENST00000435532.8 [P46934-4]
ENST00000506154.1 [P46934-2]
ENST00000503468.5
P46934
ENST00000648451.1
A0A3B3IUC1
H0Y9L1
ENST00000508342.5 [P46934-1]
H0Y8X6
ENST00000502612.5
ENST00000507063.1
H0YA37
ENST00000508871.5
ENST00000338963.6 [P46934-3]
H0Y8H4